Top Tech Startups in South America in 2026

AssemblyAI is a remote-first company building powerful AI models for developers, startups, and enterprises to transcribe and understand their audio data. Our mission is to make production-ready, state-of-the-art AI models accessible to developers and product teams at extremely large scale through simple APIs. Customers, including Spotify, Algolia, Dow Jones, Happy Scribe, BBC, The Wall Street Journal, and NBCUniversal, use our APIs to transcribe and understand millions of videos, podcasts, phone calls, and zoom meetings every day. Our APIs power innovative products like conversational intelligence platforms, meeting summarizers, content moderation, and automatic closed captioning. We're growing at breakneck speed, and recently announced our Series B round. We've raised $63M in total funding, backed by leading investors including Insight Partners, Accel, Y Combinator, Patrick and John Collision (Founders of Stripe), Nat Friedman (Former CEO of GitHub), and Daniel Gross (Entrepreneur & Investor in companies including GitHub, Uber & SpaceX). Our team is made up of problem solvers, innovators, and top AI researchers from companies like DeepMind, Google Brain, Meta AI, Amazon and Apple. They conduct cutting-edge AI research and develop novel algorithms and techniques to continually push the state-of-the-art in speech recognition and NLP. Join our world-class, remote team and help us build an iconic deep learning company!

SIGNIFYD’s full-service cloud platform simplifies fraud detection through a financial guarantee, allowing businesses to increase sales while reducing fraud losses. SIGNIFYD is in use by multiple companies on the Fortune 1000 and Internet Retailer Top 500 list.

Domino powers model-driven business for the world’s most advanced enterprises, including over 20% of the Fortune 100. Our Enterprise MLOps platform speeds up the development and deployment of data science work while increasing collaboration and governance, to scale data science into a competitive advantage. Our platform enables thousands of data scientists to develop better medicines, grow more productive crops, adapt risk models to major economic shifts, build better cars, improve customer support, or simply recommend the best purchase to make at the right time. Domino is backed by leading venture capital firms: Sequoia Capital, Bloomberg Beta, Coatue Management, Dell Technologies Capital, Highland Capital Partners, In-Q-Tel, and Zetta Venture Partners.

MongoDB is the leading modern, general purpose database platform, designed to unleash the power of software and data for developers and the applications they build. Headquartered in New York, MongoDB has more than 15,000 customers over 100 countries. The MongoDB database platform has been downloaded over 60 million times and there have been more than one million MongoDB University registrations.

LILT is a language translation services and technology company. We're building the next generation of localization, making it possible for every organization to communicate with their customers in the language of their choice through LILT's high-quality, scalable, and affordable translation services. We recruit the world's best human translators and equip them with our software, allowing them to translate better and faster than ever. By combining human expertise and machine efficiency in a complete enterprise localization solution, we can deliver technology-enabled translation services to our customers. Lilt is backed by some of the world's leading investors including Sequoia Capital, Intel Capital, and Redpoint. Our customers include some of the largest Fortune 500 companies in the world who rely on Lilt every day to provide more personal customer experiences in 300+ languages. Our team is headquartered in the Bay Area with additional hubs in Indianapolis, Washington DC, Berlin, Dublin, and the UK.

Through the development of a first of its kind open platform, Platform Science provides the hardware and software that allows clients to fully capture, analyze and apply a wealth of data, dramatically increasing performance, compliance, time management and savings.

Topsort is the leading AI and Auction-based retail media global company, transforming retailers and marketplaces into top ad networks on par with industry giants. Through seamless integration, Topsort provides a comprehensive Bidless™ retail media tech stack featuring highly flexible API tools, an industry-leading privacy-safe clean room with robust online and in-store attribution, and a transparent ad network for streamlined media buying across multiple ad networks. In just three years since launch, Topsort has raised $38 million in funding from investors like Pear Ventures, Quiet Capital, FJ Labs, and Upload Ventures.

Tremendous is the simplest way to send rewards and payouts around the world. We handle almost any form of payment that isn’t payroll. And our platform is free to use. We handle the tricky stuff that comes with sending money, so orgs can easily send rewards to research participants, sales prospects, employees, and so on in over 200 countries. We're 75 people, fully remote, highly profitable, and self-funded (yes, crazy, we know). Come work with us!

Sardine helps fintech, crypto, and web3 companies "move money confidently" by developing fraud, compliance, and payment infrastructure. With Sardine, builders can focus on growing their business instead of spending time, fighting against fraudsters. We're growing incredibly fast and powering over 100 customers around the world like Brex, MoonPay, Bakkt, Luno, Transak, Chippercash, Candy Digital, Metamask, Brave, and RelayFi.