Top Tech Startups in New England, United States in 2027

Using innovative solutions in E-Commerce/Marketplaces, Blockchain, Data Analytics and IIoT that aim to transform the chemical manufacturing, distribution, lab reagents manufacturing and analytical instruments industries.

Our AI powered platform uniquely supercharges B2B distributors sales through three channels: reps, email and e-commerce. By understanding which customers are likely to purchase each product and when, from new items to items which are frequently re-ordered our AI is able to direct sales reps on which customers to talk with and about what products. We also allow companies to send targeted emails tailored to each customer which sync with the messaging from the sales team. Finally, our customers customers get a personalized buying experience online. At one enterprise customer, we increased rep effectiveness by 9x in a control trial. At another customer, we are projected to drive a 10% increase in revenue with one year of use of our product. Reps love using our platform, saying it “makes me a killer.”

We’re building a new kind of mental health system Industry-best clinical experiences, better client outcomes, groundbreaking innovation, and access to the highest quality care. This is how we’re raising the bar for the entire industry.

Crosstie is an AI-powered workflow automation platform for property and casualty (P&C) insurance operations. Embedded directly into claims and operational workflows, Crosstie helps carriers, TPAs, self-insured organizations, and claims service partners reduce administrative burden, accelerate cycle times, and improve experiences for adjusters, claimants, and policyholders. Designed to integrate seamlessly with existing core systems, Crosstie enables organizations to operate more efficiently and deliver measurable ROI. Founded at Harvard University’s Innovation Lab and backed by MassMutual Ventures and General Catalyst, Crosstie is building a platform that is comprehensive by design, configurable out of the box, and interoperable across complex insurance environments. Learn more at crosstietech.com.

Securing the software development process, with a focus on improving developer velocity.

ReSupply is a Veteran-founded company that partners with nonprofits across the country to provide convenient, affordable, full-service donation pickups for their donors. We pick up when nonprofits can't. Our vetted pickup teams collect items that are clean, usable, and in good condition, often within 24 hours, from anywhere in your home, and deliver them directly to a local partnered nonprofit to support their mission and be reused. Learn more about our story and mission at resupply.com. To date, because of generous donors, ReSupply has kept over 80 million pounds out of landfills and delivered over $90 million in resources to our nonprofit partners. Founded in 2015, ReSupply holds official partnerships with more than 3,000 nonprofit locations across 48 states, including housing organizations, furniture banks, animal welfare groups, and community thrift programs. What we pick up: furniture, couches, mattresses, appliances, clothing, dressers, office furniture, and household goods. Explore all of our services. resupply.com/services Where we serve: donation pickups are available in communities across 48 states, including Boston, Chicago, Los Angeles, New York, Philadelphia, Phoenix, and many more. Find your area on our locations page (resupply.com/locations). Resupply is on a mission to reinvent and forever change the supply-chain of charitable contributions within the US. As a team of former military operators and logistics specialists, we know what it takes to get the right stuff to the right place — and even more personally — we know the impact that new supplies can have. We provide integrated logistics technology and services for vision-aligned Charities, Donors, and Drivers to simplify the transportation and transformation of physical goods into charitable aid. ReSupply is Giving Made Simple!

We're building an agentic care navigation platform that executes clinical and logistical workflows autonomously on behalf of patients and caregivers. The core problem: healthcare creates massive friction for patients: MyChart logins, prior-authorization denials, financial aid applications, appointment scheduling. Frontline staff (social workers, nurses) get trapped in execution work; patients miss interventions because logistics feel insurmountable. Our solution layers three components: (1) AI agents that handle MyChart access, form submission, and calendar integration autonomously; (2) a structured knowledge layer storing patient context, medical history, and action outcomes; (3) human fallback—trained navigators for emotional support and a trained offshore VMA team when confidence drops. We're oncology-first (highest stakes), launching with four activation hooks (financial aid, appointment booking, clinical-trial matching, care-team coordination) chosen by the patient. The platform runs on Firebase + Google Cloud (BAA-compliant), with SMS/iMessage as the primary interface. Traction: Techstars graduate, $1.5M raised, deployed with two nonprofits, several pharma pilots ongoing.

Our first product is an automated hair braider that reduces appointment times from hours to minutes, empowering stylists to triple their business and addressing the 8 billion hours spent braiding hair each year.

Power markets are undergoing a generational transformation. Surging electricity demand, an evolving generation mix, and growing market complexity are fundamentally changing how energy is produced, traded, and managed. Tierra is building an agentic power trading platform for physical energy assets. Our platform brings together market intelligence, forecasting, optimization, and AI-powered analysis to help energy teams make faster, smarter decisions without sacrificing transparency or control. We believe the future of energy trading lies in combining the speed and scale of artificial intelligence with the judgment and expertise of experienced operators. Founded by energy industry veterans, we're a team of engineers, data scientists, and market practitioners building the technology infrastructure for a new era of energy. Our ambition is to equip energy teams with the capabilities of a world-class trading desk and fundamentally redefine how physical energy assets are managed.

At Snout, our mission is to ensure no one ever has to make a healthcare decision for their pet based on the money in their bank account. As a modern financing alternative to traditional pet insurance, Snout wellness plans cover 100% of routine veterinary care like vaccinations, unlimited visits, and other valuable member benefits — designed to be used, not forgotten. We help pet owners prioritize care while removing financial risk for veterinary practices.