Top Mental Health Startups in 2026

Lyra is transforming mental health care through technology with a human touch to help people feel emotionally healthy at work and at home. We work with industry leaders, such as Morgan Stanley, Uber, Amgen, and other Fortune 500 companies, to improve access to effective, high-quality mental health care for their employees and their families. With our innovative digital care platform and global provider network, 10 million people can receive the best care and feel better, faster. Founded by David Ebersman, former CFO of Facebook and Genentech, Lyra has raised more than $900 million. Our roles can be full-time in our Burlingame, CA headquarters, OR virtual (remote candidates must be based in the United States).

Modern Health is a mental health benefits platform for employers. They are the only solution to cover the full spectrum of mental well-being needs through both evidence-based technology and professional support from a certified coach or therapist. Whether someone wants to proactively manage stress or treat depression, Modern Health guides people to the right care at the right time and helps companies save money in engagement and healthcare costs. Modern Health has raised over $11M from Kleiner Perkins and Y Combinator and works with top companies that want to take a proactive approach to mental well-being.

Big Health’s mission is to help millions back to good mental health by providing safe and effective non-drug alternatives for the most common mental health conditions including insomnia and anxiety. Designed by leading clinical experts, Big Health’s digital therapeutics expand access to gold standard care, including behavioral medicine, and are backed by industry-leading research and randomized controlled trials. By seamlessly integrating across the care pathway, from member engagement to billing via pharmacy benefit managers, Big Health simplifies adoption for both payers and patients, providing an inclusive, scalable, and affordable approach without serious side effects. Please note that Big Health will never contact job candidates via text message or any other messaging platform including Telegram. All official correspondence will occur through email. If you have concerns please reach out to [email protected].

We believe that mental health is just as important as physical health. We recognize that mental health issues can be complex and multifaceted, and we are dedicated to treating the whole person, not just the symptoms. We aim to create a world where mental health is no longer stigmatized or marginalized, but rather is embraced as an integral part of one's overall well-being. We believe that by providing quality care that is both evidence-based and compassionate, we can empower individuals to take charge of their mental health and achieve their full potential. We are passionate about making a positive impact on the lives of those struggling with mental health issues and we strive to be a force for positive change in the field of mental healthcare. Rula is a remote-first company. We currently hire in most U.S. states, with the exception of Hawaii.

The world doesn't need another company just because. We promised only to build tapouts if we could figure out a way to impact society for the better. By 2025, tapouts will prepare one million children to take on our future challenges by transforming stress into success. tapouts is a science-backed program that was developed by educators and scientists to create a fun and safe space that enables children, ages 4-16 years, to learn lessons that last a lifetime. tapouts’ experienced and caring certified coaches help kids learn to express feelings, improve self-control, build confidence, and make friends around the world on their online platform. The weekly live virtual group sessions are 30 minutes and filled with games (and prizes!) with an approach combining best practices across interdisciplinary fields such as psychology, neuroscience, and education

Headspace is your lifelong guide to better mental health. We make mental health support accessible to everyone, no matter their background or experience. Through our flagship Headspace app, we provide mindfulness tools for everyday life, including meditations, sleepcasts, mindful movement and focus exercises. Our enterprise offerings combine this experience with a human-centered model of care, with coaching, therapy, psychiatry and EAP services under one roof. Our team of experts ranges from mental health clinicians, to Emmy award-winning producers and data scientists, working together as one to help millions of people around the world be healthier and more productive. To learn more, please visit headspace.com.

Our mission: to eliminate every barrier to mental health. Spring Health is a comprehensive mental health benefit for employers. We help employees understand their mental health issues and connect with best-in-class providers to get the right treatment at the right time. From early detection to full recovery, Spring Health is the only clinically validated solution proven to be more effective than traditional mental healthcare. By combining the latest technology with vetted providers, we help engage 1 in 3 employees, reduce recovery times, and lower healthcare costs. We are an award-winning, passionate, and mission-driven team with the support of leaders in psychiatry, and have raised $30M to date from prominent VCs including Northzone, Rethink, Work-Bench, RRE, and General Catalyst.

Our vision at Tava is to make meaningful connection between mental health providers and clients accessible and easy.

Osmind is the platform for clinicians and researchers advancing new life-saving mental health treatments. Today, mental health disorders are one of the leading causes of death worldwide, especially among young adults, and are tied to shortening lifespans. While there have been developments in new psychiatric medications since the first FDA approval in 1954, today there is a growing movement among clinicians, patients, and researchers who are recognizing the need to accelerate new science. The Osmind treatment platform is currently used by leading interventional mental health practices to safely administer, monitor, and analyze the use of TMS, ECT, ketamine, SPRAVATO®, and psychedelic medicine for people living with moderate to severe mental health conditions. The core EHR technology is precisely developed for interventional treatment workflows and designed to support a strong therapeutic alliance, including journaling tools and assistance with health plan reimbursement, which is a significant access hurdle for millions of patients. Research from our platform is already helping to set new standards for mental health interventions. In the largest published real-world analysis of ketamine infusion therapy (KIT), we teamed up with Stanford University School of Medicine to share findings in the Journal of Affective Disorders (March 2022). Osmind is a San Francisco–based public benefit corporation led by scientists, technologists, and psychiatrists. We are backed by top investors DFJ Growth, General Catalyst, Future Ventures, Tiger Global, and Y Combinator. Come join us for an incredible amount of autonomy and ownership at a fast-growing startup working on one of the world's biggest problems.

At TalkDoc, we understand that having a mental illness is an extremely isolating experience, where most people don't even believe you suffer from a mental illness, or downplay what that might mean in your life. Patients who suffer from severe mental illness such as psychosis often go untreated until they hit the breaking point because of this. Talkdoc provides mental healthcare to patients on Medicaid, in more than 5 counties in California, through our professional corporation partnership. TalkDoc has established itself by having the best outcomes in the entire country for Medicaid. We see mental health hospital utilization rates of 0.16% per year, as compared to 3%-4% for the general Medicaid population who sees a mental health clinician. We've helped thousands of people live healthier and happier lives. We are moving from a family business to high-growth startup, and we started that three months ago. Our technology mission is to be the safest and most private form of healthcare, that keeps patient data private long-term, while still offering the most advanced technological solutions, such as AI clinical assistants in workflows.