Top B2B Startups in San Francisco, CA

6sense is a B2B predictive intelligence engine for marketing and sales. Using its private network of billions of time-sensitive intent interactions, 6sense uncovers net-new prospects at every stage of the funnel and determines which existing prospects are in market to buy. 6sense predicts what products prospects will buy, how much they will buy, and when. 6sense is backed by Bain Capital Ventures, Battery Ventures, Venrock, and Salesforce and is based in San Francisco. 6sense.com

Modern Treasury builds payment operations software for high-growth companies. Our API and app modernize payment operations for disruptive companies building products that move and track money—think: rideshare marketplaces, digital wallet, fiat-crypto onramps—providing tools that help them grow faster. Enabling real-time payments, automatic reconciliation, continuous accounting, and compliance solutions, Modern Treasury’s platform is used to reconcile over three billion dollars per month. Founded in 2018, San Francisco-based Modern Treasury is backed by Benchmark, Altimeter, SVB Capital, Salesforce Ventures, NewView Capital, and Y Combinator.

Humaans is the fastest way to onboard and manage your staff. It turns complex processes like employee onboarding, offboarding, and compensation management into simple workflows by integrating with other point solutions, such as Gsuite, Slack, Docusign, and Greenhouse. We're building a new kind of employee management system designed to help People Ops, Finance, and IT teams operate collaboratively by using the best in class point solutions they want for their staff while maintaining a central record of employee data. How do we get there? By focusing relentlessly around customers’ needs and their experience, and prioritising design, quality and performance.

Modern Health is a mental health benefits platform for employers. They are the only solution to cover the full spectrum of mental well-being needs through both evidence-based technology and professional support from a certified coach or therapist. Whether someone wants to proactively manage stress or treat depression, Modern Health guides people to the right care at the right time and helps companies save money in engagement and healthcare costs. Modern Health has raised over $11M from Kleiner Perkins and Y Combinator and works with top companies that want to take a proactive approach to mental well-being.

Check is a payroll-as-a-service API that lets you embed payroll directly in your vertical SaaS, HR, or time-tracking platform. Our API abstracts away the complexities of running payroll: tax calculation, remittance, and filing, plus the movement of money between companies and employees. This enables companies to easily build fully integrated payroll products to offer to their customers. Check believes in a future where small business owners don’t have to think about payroll — it’ll simply be embedded in the platforms they already use to run their businesses. With the strong tailwinds of (1) the rise of vertical software and (2) the growth of embedded fin-tech at our back, Check is building the infrastructure to power that future, and ultimately we believe we’ll enable thousands of new platforms, millions of businesses, and hundreds of millions of workers.

Ibexlabs is an AWS Advanced Tier Consulting partner with multiple competencies such as Security, DevOps, Healthcare and MSP. We are a team of passionate, technical and motivated engineers who help customers accelerate their cloud journey while keeping it secure following industry best practices. We are rapidly growing and looking to hire smart people who can continue fuelling our growth and be part of our success journey.

SourceIQ is a cutting-edge tech startup dedicated to revolutionizing supplier sourcing through automation. Our flagship product is a cloud-based enterprise solution that streamlines procurement and supplier management.

As Y Combinator's first cannabis start-up, Meadow launched out of the Winter 2015 class. Meadow builds powerful Point of Sale and eCommerce software for retailers in the legal cannabis industry. Meadow’s all-in-one platform allows dispensaries to sell products, manage menus and inventory, reward customers, dispatch delivery and pick-up orders, and create exceptional in-store experiences for customers. Meadow powers dispensaries and delivery services of all sizes, utilizing technology to maintain compliance with local and state regulations, scale with the Adult Use market, and create operational efficiencies that allow these businesses to thrive in a regulated industry. Meadow’s team is dedicated to making the best retail software in cannabis, and to creating a more collaborative and inclusive legal cannabis industry. To learn more about Meadow, visit getmeadow.com.

Pepper is the operating system for the independent food distributor, the $1T industry we all rely on to feed us every day. Our customers are the family-owned, regional, and specialty wholesalers feeding the restaurants in your neighborhood. We're the category leader, and we just closed a $50M Series C and are backed by Lead Edge, ICONIQ, and Greylock. Our latest agentic products handle the messy and manual workflows that the industry has run on for decades. Pepper is growing quickly, and you'll grow with us!

At Paystand, we’re not just another fintech company—we’re trailblazers in decentralized finance (DeFi), transforming how businesses manage their finances. With thriving hubs in Santa Cruz, San Francisco, Austin, Minneapolis, Mexico City, Hermosillo, and Guadalajara, we’re leading a global revolution in financial systems. Recognized on the Inc. 5000 list for five consecutive years, we’re among the fastest-growing companies reshaping the future of finance. Our Expanding Ecosystem: Paystand isn’t just a company—it’s a growing global network. With the strategic acquisitions of Teampay, a leader in spend management, and Yaydoo, a top AR and AP platform in Latin America, we’re building an expansive ecosystem designed to revolutionize financial operations and fuel business growth worldwide.