Top B2B Startups in San Francisco, CA

VAMOS (vamosx.co) helps local taxis compete with market giants, using technology designed to optimise costs, increase profits, and connect millions of people worldwide. Traditional taxi drivers face fierce competition from Uber and Lyft, often losing market share and revenue. VAMOS’s cutting-edge B2B2C technology levels the playing field, streamlining operations, attracting more riders, reducing costs, and increasing earning potential from both rides and deliveries. Introducing VAMOS: revolutionising transportation for island destinations by equipping local taxi drivers with advanced technology to reach more riders and boost their earnings. Our intuitive app delivers smarter, faster, and greener rides, transforming every journey into a seamless experience. Sustainability impact: At VAMOS, we are committed to creating a lasting positive impact in destinations around the world. By allocating a percentage of our revenue to community development initiatives, we directly support local education, infrastructure, and environmental conservation efforts.

Samara Aerospace provides spacecraft design and satellite control technology services. The company develops the Hummingbird satellite bus, leveraging its proprietary MSAC (Multifunctional Structures for Attitude Control) system to achieve precise attitude control and active jitter cancellation without traditional reaction wheels. It supports integration of solar-panel–embedded piezoelectric actuators for high-precision pointing in Earth observation and optical‑communications missions.

We’re a hypergrowth AI startup backed by top-tier VC firms. We’ve created a new paradigm for enterprise artificial intelligence with a breakthrough technology called Organizational Memory (OM1). It’s fundamentally reshaping how people do work. Unlike any other AI product, OM1 builds “a brain” for companies–knows what’s happening in real time across the whole business, and has all the output capabilities of a human employee. Roles like Product, Engineering, G2M, and Management will never be the same. And while we’re starting by selling our technology to other software businesses, we have the ability to serve hundreds of different industries. We're not just building another productivity tool. We're ushering in a fundamental revolution in how humans do work. With proven product-market fit, rapid YoY ARR growth, and household-name customers, we’re expanding our team to dominate what will be a $10T+ industry. And we’re only just getting started.

Mercata is a secure AI sidekick for fundamental investors. We turn unstructured internal and external data into a real-time, queryable research environment so analysts and portfolio managers can move faster, ask better questions, and make more confident decisions. With Mercata, research teams ask layered, high-context questions that traverse companies, people, and time, and get traceable, source-linked answers. The system scans filings, press releases, and news in real time and surfaces what is new and factual, highlighting potential impacts on existing investment theses. It frees analysts from data mining so they can produce unique insights and apply their judgment. Teams can integrate proprietary research into Mercata’s dynamic intelligence layer, creating a unified system of record for faster recall, deeper analysis, and clear decision trails.

Software solutions for the pharmaceutical industry.

Assured QA is an enterprise-grade automated software testing infrastructure designed to eliminate bottlenecks in modern development cycles. Legacy QA pipelines slow down deployment, drain engineering resources, and break under scale. We solve this by providing a robust, self-serve automated testing machine that integrates directly into enterprise workflows, allowing engineering teams to ship code faster with absolute confidence. We are an engineering-led startup. We have successfully built, launched, and bootstrapped version 1 of our architecture to active revenue, achieving definitive market validation. We are currently scaling our proprietary version 2 infrastructure to handle complex, high-velocity enterprise demands. Our foundation is rooted in deep systems architecture, autonomous execution, and solving the hardest infrastructure problems in the developer tools space.

Create lets you turn English into full stack apps. It's an AI "text to app" builder for entrepreneurs. Our mission is to give everyone the power of software creation. Our ambitious first step is to power a new generation of entrepreneurs as their AI product engineer. We’re hiring for the early team (first 10) who want to create an iconic product and shape our culture. Our team is small and talent-dense. We’ve built products people love and look for people who care about building insanely great products. Our investors include Bessemer, Uncork and the founders of Shopify, Zapier, Turing, Docsend, Front, Intercom, Shippo, and more.

Uplane (YC F25) replaces marketing agencies with AI. We generate hundreds of ads with matching landing pages and steer the ad spend across channels like Meta, Google, LinkedIn and others. By connecting to CRM and ERP data, Uplane learns what drives profits and continuously improves campaigns. Companies waste billions on bad ads, mismatched landing pages, and poor budget allocation. Uplane fixes this by replacing a patchwork of agencies, spreadsheets, and siloed tools with one self-improving system. The result: Higher ROAS for enterprises and effortless, expert-level marketing for SMBs.