Top Tech Startups in Iowa, US in 2026

The HYPR Cloud Platform makes it easy to eliminate passwords and deliver lightning-fast login experiences that users love. With HYPR, businesses are finally able to stop phishing, reduce fraud, and enable unrivaled security for employees and customers across the globe. Welcome to The Passwordless Company® The HYPR Cloud Platform makes it easy to go Passwordless across the enterprise by combining the security of a smart card with the convenience of a smartphone. With HYPR, businesses are finally able to solve the desktop MFA gap, eliminate customer passwords, and deliver lightning-fast login experiences their users love. #EliminateTheTarget at HYPR.com

PermitFlow is redefining how America builds. We’re an applied AI company serving the nation’s builders, tackling one of the largest information challenges in the economy: understanding what can be built, where, and how. Our AI agent workforce helps the fastest-growing construction companies navigate everything from permitting and licensing to inspections and project closeouts – accelerating housing, clean-energy, and infrastructure development across the country. Despite being a $1.6T industry, construction still suffers from massive delays, wasted capital, and lost opportunity. PermitFlow has already delivered unprecedented speed, accuracy, and visibility to over $20B in development, helping contractors reduce compliance time, de-risk projects, and scale with confidence. America is entering a CAPEX super-cycle, from data centers and factories to housing and renewables, and joining PermitFlow is building the AI at the heart of every construction project powering the next wave of re-industrialization. We’ve raised over $90M, most recently completing our Series B, from top-tier investors including Accel, Kleiner Perkins, Initialized, Y Combinator, Felicis, and Altos Ventures, with backing from leaders at OpenAI, Google, Procore, ServiceTitan, Zillow, PlanGrid, and Uber.

Chowbus is a food ordering platform which curates featured dishes from selected ethnic restaurants daily and delivers them fresh and hot to your home or office affordably with the tap of your cell phone. We provide dish-centric mobile ordering experience for consumers to easily explore and order authentic ethnic food and we empower local ethnic restaurants with the technology, tools, and marketing to grow their business.

Glacier’s goal of ending waste begins with the recycling industry. We’re launching an AI-based sorting robot that is significantly cheaper and more portable than the competition, without sacrificing accuracy. Using our robot, recycling facilities can process America’s trash more cleanly and efficiently, meaning more manufacturers can use recycled commodities as a viable alternative to our precious natural resources.

ComplyAdvantage is helping firms rethink how they combat financial crime and comply with regulations (specifically around Sanctions, AML and CTF). The team is on a personal mission to combat the rising threat of terrorism and fight the negative impact on society of money laundering. ComplyAdvantage's proprietary, dynamic global database of individuals, organisations and all their connections, provides fresh insight into financial crime risks (e.g. Sanctions, Watchlists, Politically Exposed Persons, Adverse Media). ComplyAdvantage's screening platform helps to safely automate the risk assessment of customers and transactions, and their real-time analytics enable firms to monitor customer activity and spot suspicious behaviours. ComplyAdvantage uses machine learning and big data coupled with a tailored risk-based approach to help a wide range of insurance companies and financial institutions improve automation, reduce manual work (‘false positives’) and make decisions faster.

Machinio.com is one of the world’s largest platforms connecting buyers and sellers of inventory and related services across multiple industries. Founded in 2013 and acquired in 2018, Machinio now serves over 4,000 paying clients globally and continues to expand its reach and impact. Thousands of dealers and suppliers rely on the platform to market and sell their equipment, connecting them with millions of prospective buyers each year. Machinio is widely recognized for leveraging technology to simplify and modernize the buying and selling process. By introducing innovative tools and improving marketplace efficiency, the company has helped both buyers and sellers save significant time while facilitating high-value transactions worldwide. Machinio System is Machinio’s all-in-one software solution built specifically for dealers and service providers. Launched in 2018, it combines modern, fully customizable, SEO-optimized websites with a fully integrated CRM platform for dealers. This unified solution enables businesses to manage their entire workflow in one place — including inventory, lead management, quoting, invoicing, contact databases, email marketing campaigns, and more. With continuous feature development and a strong product roadmap, Machinio System empowers dealers and service providers to maintain a professional online presence, leverage intelligent sales and marketing tools, and consistently generate and nurture business opportunities. Machinio has been featured in leading media outlets including Forbes, Business Insider, Inc., EquipmentWorld, Agriculture.com, and others.

Gridline is here to redefine how private markets operate, making them faster, smarter, and more accessible. We are setting a new standard by building the Turnkey Alternatives Management Platform (TAMP) to help wealth managers run private market programs at scale. As a ledger-native system of record, Gridline provides a single source of truth that tracks the entire investment lifecycle down to the transaction layer, enabling RIAs, family offices, and private banks to manage their private markets business in one place. Our team brings deep experience across both enterprise technology and alternative investments to build the infrastructure layer the industry has always lacked. Backed by an $18.5M Series A led by FINTOP, we are creating the systems and structuring the data required to define the next generation of private market investing. Are you up to the challenge?

Iterative Health is pioneering the use of artificial intelligence-based precision medicine in gastroenterology (GI), with the aim of helping to optimize clinical trials investigating treatment of inflammatory bowel disease (IBD). We use advanced machine learning and computer vision to interpret endoscopic images along with other types of data, helping clinicians to better assess patients with potential GI problems. This gives practitioners enhanced capabilities in the detection, annotation, disease scoring and treatment of GI related diseases. Iterative Health is initially applying these advances towards standardizing disease severity characterization for inflammatory bowel disease. Ultimately, the company aims to establish more meaningful endpoints to serve as better predictors of both therapeutic response and disease outcomes. The company is headquartered in Cambridge, Massachusetts.

Optime-Tech is a technology, consulting and global IT service provider. With our core values of customer centricity, agility and innovation, we partner with our customers to help drive positive outcomes. We work relentlessly and systematically to exhaust every avenue in bringing our clients the best available services, our approach is substantial, our passion, enthusiasm and dedication is evident.