Top Digital Health Startups in 2026

Spruce is a communication software platform built for independent healthcare practices. Our HIPAA-grade, cloud-based solution integrates a business phone system with texting, faxing, and telemedicine—optimizing care collaboration, streamlining patient interactions, and ensuring accountability. Trusted by tens of thousands of healthcare organizations across the U.S. and backed by over 60,000 5-star reviews, Spruce is transforming healthcare communication.

Big Health’s mission is to help millions back to good mental health by providing safe and effective non-drug alternatives for the most common mental health conditions including insomnia and anxiety. Designed by leading clinical experts, Big Health’s digital therapeutics expand access to gold standard care, including behavioral medicine, and are backed by industry-leading research and randomized controlled trials. By seamlessly integrating across the care pathway, from member engagement to billing via pharmacy benefit managers, Big Health simplifies adoption for both payers and patients, providing an inclusive, scalable, and affordable approach without serious side effects. Please note that Big Health will never contact job candidates via text message or any other messaging platform including Telegram. All official correspondence will occur through email. If you have concerns please reach out to [email protected].

Our story started when our co-founders, whilst working as medical doctors, recognized that the holistic textbook version of medicine was not at all what was being provided for patients. The reality is that a stretched healthcare system fails to engage people in their medical care at the preventative stages. As a result, the $3 trillion currently spent on healthcare goes on to prevents only 10% of premature deaths. With digital therapeutics, we have the opportunity to prevent 40% of premature deaths that are caused by behavioral patterns. Quit Genius is a behavior change platform that combines digital coaching, personalized content, wearable technology and medication to help people overcome addictive behaviors.

Needing to see a doctor is hard. Getting care shouldn't be. Luma's Patient Success Platform™ unifies and automates each of a patient's healthcare journeys -- access & operational, clinical, and financial -- to help them be healthier. It integrates with more than 80 EHRs to give staff and clinicians a fuller view of the patient with less manual outreach. With Luma, healthcare organizations see an average of 37% more referred patients in the first six months, and achieve a 39% average revenue increase.

Our mission: to eliminate every barrier to mental health. Spring Health is a comprehensive mental health benefit for employers. We help employees understand their mental health issues and connect with best-in-class providers to get the right treatment at the right time. From early detection to full recovery, Spring Health is the only clinically validated solution proven to be more effective than traditional mental healthcare. By combining the latest technology with vetted providers, we help engage 1 in 3 employees, reduce recovery times, and lower healthcare costs. We are an award-winning, passionate, and mission-driven team with the support of leaders in psychiatry, and have raised $30M to date from prominent VCs including Northzone, Rethink, Work-Bench, RRE, and General Catalyst.

The Verse: Building Games That Heal **THE VERSE OVERVIEW**: The Verse creates games, experiences, and rituals that uplift humanity. **WHO WE ARE:** The Verse is a global community of inspired gamers, developers, designers, scientists, artists, visionaries, teachers, and students who join together to passionately contribute their wide-ranging expertise to invent experiences that enhance human flourishing. **MISSION:** Our mission is to collaboratively create digital therapeutics and experiences that are playful, embodied, and ritual-enriched, that invite co-creation and foster participation and that enhance health, improve well-being and raise consciousness.

As population continues to age, there is a growing demand for motor rehabilitation services. The problem is that the way we address this growth or rehabilitation services (physical therapy) has not changed in thirty years because we are still heavily reliant on a one-to-one patient therapist interaction which is costly, non scalable, and difficult to ensure consistent quality. At SWORD Health, we saw the opportunity to take a truly disruptive and transformative approach to this problem by creating the first digital therapy solution that addresses the growing demand for therapy while reducing costs, empowering patients with their recovery to ultimately recover faster, and providing a rich source of data for clinical teams and decision makers. Video: vimeo.com/118489111

Carrot Fertility is the leading global fertility care platform, serving people of every age, race, income, sex, sexual orientation, gender, marital status, and geography. Trusted by hundreds of multinational employers, health plans, and health systems, Carrot's comprehensive clinical program delivers industry-leading cost savings for employers and award-winning experiences for millions of people worldwide. Whether there is a need for care through fertility preservation, male-factor infertility, pre-pregnancy, IVF, pregnancy and postpartum, adoption, gestational surrogacy, or menopause, Carrot supports members and their families through many of the most memorable and meaningful moments of their lives. With Carrot, you can pursue your possible. Carrot has received national and international recognition for its pioneering work, including Best Diversity, Equity, & Inclusion Product from the Anthem Awards, Fast Company's Most Innovative Companies, CNBC's 100 Barrier Breaking Startups, and more. Carrot is regularly featured in media reporting on issues related to the future of work, women in leadership, healthcare innovation and diversity, equity, and inclusion, including MSNBC, The Economist, Bloomberg, The Wall Street Journal, CNBC, National Public Radio, Harvard Business Review, and more. Carrot is a remote-first company with teams in more than 40 states across the United States and dozens of countries around the world. It has received numerous workplace awards, including Fortune's Best Workplaces in Healthcare, Quartz’s Best Companies for Remote Workers, and Great Place to Work and Age-Friendly Employer certifications. Learn more at carrotfertility.com.

iSono Health is developing AI-powered solutions for accessible and personalized health monitoring . Our first solution, ATUSA, combines a wearable, automated ultrasound and AI to transform breast cancer screening by increasing quality, improving access, and lowering cost. ATUSA system produces repeatable 3D images, independent of operator skill in 1min, enabling accurate and rapid diagnosis. iSono Health’s deep learning technology extracts acoustic biomarkers from quantitative ultrasound data to identify and track functional properties of breast tissue enabling early detection and monitoring of breast cancer.

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