Top Tech Startups in California, US in 2026

At 4Catalyzer we strive to transform 21st century medicine by solving today’s most challenging problems – across life science research tools, medical devices and therapeutics. We aspire to create significant societal impact and are motivated by the idea that our products will change the lives of people we love. Fundamentally, we are focused on developing new types of sensors and pairing them with deep learning to get a window into biology and medicine that nobody has ever had before. We have audacious plans – but we have an unbeatable team and a founder that has disrupted biomedical science successfully more than once. If you have experience in image reconstruction, mixed-signal IC design, high-speed electronics, nanophotonics, microfabrication, MEMs, biophysics, biochemistry, molecular biology, deep learning, cloud computing, embedded systems, or hold any dual degree with distinction along with computer science please contact us and “put a dent in the universe”.

We feel that the best way to work towards eliminating the tobacco-related harm is twofold: intelligently designing tobacco-free nicotine products and making them easy for customers to buy online. Our small team of entrepreneurs, scientists, and nicotine enthusiasts has served over 100,000 customers who, like us, knew there had to be a better way to enjoy nicotine.

CookUnity is the first-ever chef-to-consumer platform. Connecting a diverse group of talented chefs with busy food lovers, we’re elevating the at-home dining experience. On a quest to unlock the world’s best food creators and bring their meals to the masses, CookUnity is home to more than 35 of NYC and LA’s most talented chefs. Through a weekly subscription, consumers can select from a robust and ever-changing menu of handcrafted meals that cater to a wide variety of palates and dietary preferences. Delivering more than 3.5M meals per year and growing 5x YoY, CookUnity is also helping Chefs double their income and build their own teams under their personal brands. Believing that healthy food fuels stronger communities, CookUnity contributes to an ongoing partnership and donation with the Food Bank For New York City, the city’s major hunger-relief organization working to end food poverty across all five boroughs. A growing startup with kitchens in Brooklyn and Los Angeles, CookUnity reaches subscribers throughout the country, with ambitious expansion planned for 2021. Join Us!

At Magical, we're driven by a mission to change the future of work, empowering organizations by automating their most complex and essential manual workflows. We're building a new, innovative, and cutting-edge AI-first automation platform with reliability at the core. Join us and shape the future of work!

Quantum computing has the potential to impact every area of human society for the better--our goal is to build computers to redefine industries like medicine, materials science, finance, artificial intelligence, machine learning, cryptography, and more.

We invest in companies that define new markets, including Airbnb, AppDynamics, Arista Networks Cloudera, Coinbase, Discord, Dropbox, Facebook, Figma, Instagram, LinkedIn, Medium, Nextdoor, Okta, Pure Storage, and Roblox.

Avela is a platform for organizations and governments to run markets to equitably allocate resources and opportunities. The right person in the right position will change the world. Learning opportunities, field-based experiences, and consultant projects all have something in common. Currently, these opportunities are allocated through a combination of manual processes, spreadsheets, and trial-and-error - rife with implicit bias and questionable outcomes. Our mission is to more equitably and efficiently distribute opportunity. Learn more at avela.org

With access to a diverse pool of skilled, qualified IT consultants, InfoStride can provide staff on an on-demand and permanent basis throughout the USA and India. We provide Management solutions, Digital transformation, Cloud migration and enablement, Data analytics and visualization, quality engineering and Esurance, Develops and automation services.

As Y Combinator's first cannabis start-up, Meadow launched out of the Winter 2015 class. Meadow builds powerful Point of Sale and eCommerce software for retailers in the legal cannabis industry. Meadow’s all-in-one platform allows dispensaries to sell products, manage menus and inventory, reward customers, dispatch delivery and pick-up orders, and create exceptional in-store experiences for customers. Meadow powers dispensaries and delivery services of all sizes, utilizing technology to maintain compliance with local and state regulations, scale with the Adult Use market, and create operational efficiencies that allow these businesses to thrive in a regulated industry. Meadow’s team is dedicated to making the best retail software in cannabis, and to creating a more collaborative and inclusive legal cannabis industry. To learn more about Meadow, visit getmeadow.com.

NextRoll is a leading marketing technology company that empowers businesses to drive sustainable growth while building trusted connections with their audiences. Built on nearly two decades of AI and data expertise, NextRoll delivers its solutions through AdRoll, its flagship brand and connected advertising platform. The AdRoll platform brings together two powerful offerings: the AdRoll product, which helps brands generate awareness, deepen engagement, and drive measurable revenue through AI-powered multi-channel campaigns; and AdRoll ABM, a full-funnel account-based marketing product that unifies buyer insights, predictive AI, and multi-touch advertising to accelerate pipeline and revenue for B2B teams. Together, these solutions give marketers the clarity, efficiency, and performance they need to grow with confidence. NextRoll is a privately held company headquartered in San Francisco, CA.