Top Tech Startups in Durham, NC in 2027

TrialSpark is transforming the way new medical treatments are brought to market. We’re a technology company that runs end-to-end clinical trials through a network of our own TrialSpark-operated trial sites, making the entire lifecycle of clinical trials more efficient, accessible, and patient-centric. We're growing quickly and would love to have you join us!

SourceIQ is a cutting-edge tech startup dedicated to revolutionizing supplier sourcing through automation. Our flagship product is a cloud-based enterprise solution that streamlines procurement and supplier management.

AirGarage is repurposing the 30% of real estate in the average American city currently dedicated to parking. We are building a future where real estate is digitized and can be transitioned from one use to another seamlessly on-demand, moving every piece of urban real estate toward its highest and best use. We are starting with the $131 billion US parking real estate market because it is one of the most offline and mismanaged commercial real estate asset types. As a full-stack parking operator, we automate the operation of parking lots and parking garages. We handle everything from advertising to collecting payments from drivers and enforcing against illegal parking. We already operate 150+ parking lots and parking garages across 30 US states and we are growing quickly. We are backed by top tier investors including Andreessen Horowitz, Floodgate, Founders Fund, and angel investors who have founded or worked at companies like Uber, Opendoor, Flexport, and more.

One Medical is the fastest growing primary care practice in the country. But this is no ordinary doctor’s office. Everything we do is built around how people live today. From our office experience to the exceptional people we hire to technology that simplifies getting — and giving — care, we’re transforming healthcare and truly changing people’s lives.

Google’s mission is to organize the world’s information and make it universally accessible and useful.

Our mission is to make technical advances towards robots and humans working together side by side, with an emphasis on human-centric design. Diligent Robotics is developing a suite of artificial intelligence that enables robots to collaborate with and adapt to humans in everyday environments. Our first product is a hospital service robot that can assist clinical staff with logistical tasks, allowing them to spend more of their time on direct patient care, improving patient satisfaction, quality of service, and safety.

ShelfCycle is a SaaS company building a modern platform for chemical distributors. Our customers are businesses that store chemical products in warehouses and sell+distribute them to consumers/manufacturers in auto, ag, cosmetics, consumer products...virtually every industry. The name of the game for distributors is how quickly they can cycle the inventory on their shelves - and that's what our product helps them do every day.

Alpaca Health enables clinicians to become entrepreneurs, starting in autism care. We help clinicians launch and scale their own clinics by providing AI-powered software, payer contracting, and full back-office infrastructure. Our goal is simple: shift power in healthcare away from large consolidated entities and back to clinicians. We've raised over $14M in funding from early-stage investors like Core Innovation Capital, Adverb Ventures, and South Park Commons, and are building for long-term category leadership. More importantly, we're serving hundreds of patients, while growing 30% MoM.

We’re giving the power of digital advertising to the people. Our job is to ensure that anyone has the tools they need to make their voice heard online. We’re a team of technologists, nonprofit leaders, and entrepreneurs driven by purpose and committed to the free exercise of our human agency.