Top Tech Startups in St. Louis, MO in 2027

Today, there's more data and users outside the enterprise than inside, causing the network perimeter as we know it to dissolve. We realized a new perimeter was needed, one that is built in the cloud and follows and protects data wherever it goes, so we started Netskope to redefine Cloud, Network and Data Security. Since 2012, we have built the market-leading cloud security company and an award-winning culture powered by hundreds of employees spread across offices in Santa Clara, St. Louis, Bangalore, London, Melbourne, and Tokyo. Our core values are openness, honesty, and transparency, and we purposely developed our open desk layouts and large meeting spaces to support and promote partnerships, collaboration, and teamwork. From catered lunches and office celebrations to employee recognition events (pre and hopefully post-Covid) and social professional groups such as the Awesome Women of Netskope (AWON), we strive to keep work fun, supportive and interactive. Visit us at Netskope Careers. Follow us on LinkedIn and Twitter @Netskope for more updates.

There will be a shortage of 1.5 million healthcare workers in 5 years. There are 37 million workers who could double their income with short vocational training. Stepful will bridge this gap. Stepful is the first online school disrupting healthcare vocational training by offering a new student experience, and guaranteeing job outcomes.

Better data leads to more performant models. Performant models lead to faster deployment. We help deliver value from AI investments faster with better data by providing an end-to-end solution to manage the entire ML lifecycle.

Varsity Tutors is a live learning platform that connects students and professionals with personalized instruction to achieve any goal. To date, students have accessed more than three million hours of live instruction on the platform. Experts are available to meet in person or through the company’s award-winning online and mobile platforms, which account for the majority of all sessions.

We reduce waste, cut costs, and improve revenue by improving throughput, asset utilization and staff productivity. Our platform uses AI, RTLS, and EHR data to enable self-learning agents to automate workflows, adapt in real-time, and orchestrate all of care delivery operations. Easy to deploy and scale, it gives a clear picture of spaces, equipment, and people, eliminating inefficiencies and enhancing the patient experience. With measurable 10X ROI and over 20+ use cases, Kontakt.io is the go-to platform for better and faster care delivery operations.

Wider Circle is a neighborhood-based health organization that empowers members of the same community to live happier, healthier lives.

We’re giving the power of digital advertising to the people. Our job is to ensure that anyone has the tools they need to make their voice heard online. We’re a team of technologists, nonprofit leaders, and entrepreneurs driven by purpose and committed to the free exercise of our human agency.

Untapped Solutions is a venture-backed SaaS company building AI-powered CRM and outcomes technology for nonprofits, correctional facilities, and government agencies serving justice-impacted and underserved communities. Traditional case management systems are fragmented, manual, and built for tracking—not outcomes. We’re changing that by combining modern CRM infrastructure with AI-assisted workflows that automate referrals, surface real-time opportunities, and help frontline staff move clients into jobs, housing, healthcare, and training faster. Our platform integrates with existing systems (including Salesforce) rather than replacing them, allowing organizations to modernize without disruption. Clients and staff use web and mobile tools to manage referrals, access resources, and track progress in real time. We are backed by Google, Dream.Org, and Robin Hood Foundation, and have been featured in CNN, PBS, and the Financial Times. Today, Untapped Solutions partners with over 100 organizations nationally and supports a growing network of job seekers and service participants. We are a mission-driven but revenue-focused company. We move fast, operate with ownership, and expect our team to build, test, and improve in real-world conditions. Early hires at Untapped shape how the company grows.