Top Artificial Intelligence Startups in San Francisco, CA

Our goal at P-1 AI is to develop an artificial general engineering intelligence—and eventually superintelligence—that can help the human species design physical systems more efficiently and at unprecedented levels of complexity. Going beyond existing foundation models, our autonomous AI agent learns from synthetic training data and real-world feedback and reasons over an internal multi-physics representation of a product design that encompasses both geometry and function. We are a world-class team of AI researchers, engineers, and top industry executives backed by some of the best investors in Silicon Valley and beyond.

PhrasIQ is building decision infrastructure for enterprise finance. Enterprises have invested heavily in Systems of Record to store data, Systems of Analytics to understand data, and increasingly Systems of Intelligence to generate answers. Yet critical business decisions remain slow because finance teams must reconcile fragmented data, validate assumptions, investigate variances, and defend their reasoning before action can be taken. We call this decision latency. Our core belief is that trust, not AI capability, is the primary bottleneck in enterprise decision-making. Rather than applying AI directly to fragmented enterprise data, PhrasIQ establishes structured truth first through deterministic reconciliation, lineage tracking, governance, and auditability. On this trusted foundation, our decision intelligence platform delivers explainable forecasts, variance analysis, anomaly detection, and decision recommendations. Beyond helping teams make faster decisions, PhrasIQ captures the assumptions, reasoning, decisions, outcomes, and learnings behind every decision, transforming them into persistent organizational decision intelligence. We believe this represents the next foundational enterprise software category: Systems of Decision. We are initially focused on enterprise finance, where trust, accountability, and auditability are mission-critical, with a long-term vision of becoming the decision infrastructure layer for modern enterprises.

At Toi Labs, we’re pioneering the next frontier of personal health monitoring—starting in the most unexpected place: the bathroom. By transforming the toilet into a passive health companion, we deliver real-time, actionable insights into gut health and more—without requiring users to change their behavior. Our platform enables early detection and preventive care right from the home. Recognized by TIME as a Best Invention of the Year and backed by TOTO, Sloan and the NIH, we’re combining elegant design, embedded technology, and data science to redefine how—and where—healthcare happens.

Afresh is on a mission to reduce food waste and increase access to nutritious food globally by transforming the fresh food supply chain. Our AI-powered solutions optimize the multi-trillion-dollar grocery industry's food ordering, production, and merchandising processes. We built the first platform capable of handling all of Fresh food’s complexities. We are relentlessly focused on helping grocers reduce waste, increase profitability, and bring better, fresher food to their communities. Afresh is currently deployed in hundreds of grocery stores across the United States and is on track to reduce 30 million pounds of food waste per year with our existing customers alone. By 2021, we're aiming to reduce food waste by a quarter billion pounds per year. We are a passionate team united by our mission to make an impact. As an Afresh employee, you’ll own meaningful work that will challenge you and change the future of how fresh, nutritious food makes its way through the supply chain. We hope you’ll join us!

TrueFoundry is an Enterprise Platform as a service that enables companies to build, ship and govern Agentic AI applications securely, at scale and with reliability through its AI Gateway and Agentic Deployment platform. Its AI Gateway encompasses a combination of - LLM Gateway, MCP Gateway and Agent Gateway - enabling enterprises to manage, observe, and govern access to all components of a Gen AI Application from a single control plane while ensuring proper FinOps controls. Its Agentic Deployment platform enables organizations to deploy models on GPUs using best practices, run and scale AI agents, and host MCP servers - all within the same Kubernetes-native platform. It supports on-premise, multi-cloud or Hybrid installation for both the AI Gateway and deployment environments, offers data residency and ensures enterprise-grade compliance with SOC 2, HIPAA, EU AI Act and ITAR standards. Leading Fortune 1000 companies like Resmed, Siemens Healthineers, Automation Anywhere, Zscaler, Nvidia and others trust TrueFoundry to accelerate innovation and deliver AI at scale, with 10Bn + requests per month processed via its AI Gateway and more than 1000+ clusters managed by its Agentic deployment platform. TrueFoundry’s vision is to become the Central control plane for running Agentic AI at scale within enterprises and empowering it with intelligence so that the multi-agent systems become a self-sustaining ecosystem driving unparalleled speed and innovation for businesses. To learn more about TrueFoundry, visit truefoundry.com.

nOps is an automated cloud optimization platform that makes it easy to allocate and manage cloud usage, commitments, and spend. Managing $4B+ in annual cloud spend, nOps helps companies of every size, from fast-growing startups to global enterprises, reclaim millions in wasted cloud costs. Cloud waste is one of the fastest growing challenges in tech. nOps tackles it by leveraging proprietary ML modeling and AI-powered automation to guide organizations toward the right commitment strategy. The platform eliminates manual provisioning entirely, delivering maximum cost savings without sacrificing reliability, so teams can focus on building and innovating. Trusted by innovative brands around the world, nOps has been recognized as a G2 Top 50 Security Product and G2 Leader for Winter 2025, is an AWS Advanced Technology Partner, and a proud FinOps Foundation Member with our CEO serving on the FinOps Foundation Governing Board.

Hospitable, an Inc. 5000 company, gifts short-term rental hosts their valuable time back. Founded in 2016, Hospitable’s tools allow hosts to automate the most time-consuming elements of hosting. Hosts use Hospitable to answer 90% of guest messages with AI-powered automated messaging, to automate their team notifications so they never miss a clean, and to avoid double bookings with a synchronized calendar across booking channels. Hospitable allows hosts to build their own direct booking website with guest vetting, $5M damage protection, and payment processing built-in. Hospitable also connects with popular 3rd party online travel agencies such as Airbnb, Vrbo, and [Booking.com](booking.com).

Come help us build the future of enterprise video security. We've signed up flagship customers across a variety of verticals. As an early engineer in a rapidly growing market, you have the opportunity to make a huge impact at LiveReach AI. livereach.ai

The architectures that power modern AI were designed for language, not for science. They were never built to understand DNA, interpret experiments, or learn the rules that govern living systems. Closing this gap represents one of the defining opportunities of our time. Our team has pioneered advances across frontier AI, including the first models trained with one-million-token context windows, and now scaling toward one billion. We focus on innovations on systems and architecture, because building AI for science demands a fundamentally different foundation. As a first application of this technology engine, we are advancing AI for life, the most complex and consequential domain of all. We are the AI team behind Evo and Evo 2, the generative genomics models used to create real gene-editing tools and the first whole genomes designed entirely by AI. That work demonstrated that AI can create biology, not just analyze it. We are now building multimodal models trained directly on the fabric of biology, enabling faster discovery, deeper understanding, and entirely new capabilities. As we push the frontier of scientific world models, we will build systems hand-in-hand to ensure global biological resilience: rapid detection, rapid response, and rapid countermeasures against emerging threats, both natural and synthetic. Our mission is ambitious: to reimagine what AI can do for science, and to build that future.

We’re killing manual review workflows and replacing them with AI agents. Not just faster or cheaper. Fundamentally better. We’re already working with global brands where approvals used to take a week. Now, teams can launch in under an hour, without adding headcount. Our mission is to kill the review. Free people to do meaningful work.