Top Artificial Intelligence Startups in San Francisco, CA

We are providing a complete “business in a box” solution for owner-operators and small trucking carriers at a much lower cost using software engineering, data science and world class operations processes. Our mission is simple — to put more money in the hands of truck drivers and reduce their headaches. CloudTrucks will improve the three core metrics that every truck driver cares about — revenue, cash-flow and costs. We focus on the owner-operator and small trucking companies because they are the lifeblood of the industry and facing the largest pressures with fast rising insurance rates, predatory factoring options and a quickly changing landscape. It’s more important than ever to have someone in their corner whose incentives are 100% aligned with theirs.

Opal Security is intelligent access management that empowers enterprises to move fast while staying secure. Our mission is to bring clarity, control, and confidence to complex enterprise environments, helping teams govern access without slowing down innovation.

Uncountable has built an enterprise software platform for R&D organizations to minimize the number of experiments required to reach a higher level of performance. By using the platform, scientists have instant access and search-ability to all of their previous formulations, instead of digging through disparate spreadsheets. And with previous experimental records properly structured and stored, Uncountable's artificial intelligence engine can be manipulated to provide the best formulation suggestions in order to achieve new product goals.

We have built an AI powered food and exercise as medicine platform to improve treatments for Metabolic Syndrome and Reduce Readmissions.

PhrasIQ is building decision infrastructure for enterprise finance. Enterprises have invested heavily in Systems of Record to store data, Systems of Analytics to understand data, and increasingly Systems of Intelligence to generate answers. Yet critical business decisions remain slow because finance teams must reconcile fragmented data, validate assumptions, investigate variances, and defend their reasoning before action can be taken. We call this decision latency. Our core belief is that trust, not AI capability, is the primary bottleneck in enterprise decision-making. Rather than applying AI directly to fragmented enterprise data, PhrasIQ establishes structured truth first through deterministic reconciliation, lineage tracking, governance, and auditability. On this trusted foundation, our decision intelligence platform delivers explainable forecasts, variance analysis, anomaly detection, and decision recommendations. Beyond helping teams make faster decisions, PhrasIQ captures the assumptions, reasoning, decisions, outcomes, and learnings behind every decision, transforming them into persistent organizational decision intelligence. We believe this represents the next foundational enterprise software category: Systems of Decision. We are initially focused on enterprise finance, where trust, accountability, and auditability are mission-critical, with a long-term vision of becoming the decision infrastructure layer for modern enterprises.

General Compute is the neocloud for alternative chips. Inference is fragmenting: purpose-built silicon from SambaNova, Cerebras, Positron, d-Matrix, and others already beats GPUs on decode, and we productionize that hardware — we buy the racks, find the data center space, and run it for our customers. Each piece of hardware runs the workload it's actually built for: prefill stays on GPUs, decode moves to the chip built for it, and today that means generating tokens 5–7× faster than existing GPU-based competitors. Our customers are frontier labs, fast-growing AI application companies, and asset-light clouds. We closed a $15M seed round in May 2026, and have since closed a $400M debt facility — $100M funded upfront by Upper90, with the balance available for drawdown — collateralized by our inference chips.

At Toi Labs, we’re pioneering the next frontier of personal health monitoring—starting in the most unexpected place: the bathroom. By transforming the toilet into a passive health companion, we deliver real-time, actionable insights into gut health and more—without requiring users to change their behavior. Our platform enables early detection and preventive care right from the home. Recognized by TIME as a Best Invention of the Year and backed by TOTO, Sloan and the NIH, we’re combining elegant design, embedded technology, and data science to redefine how—and where—healthcare happens.

TrueFoundry is an Enterprise Platform as a service that enables companies to build, ship and govern Agentic AI applications securely, at scale and with reliability through its AI Gateway and Agentic Deployment platform. Its AI Gateway encompasses a combination of - LLM Gateway, MCP Gateway and Agent Gateway - enabling enterprises to manage, observe, and govern access to all components of a Gen AI Application from a single control plane while ensuring proper FinOps controls. Its Agentic Deployment platform enables organizations to deploy models on GPUs using best practices, run and scale AI agents, and host MCP servers - all within the same Kubernetes-native platform. It supports on-premise, multi-cloud or Hybrid installation for both the AI Gateway and deployment environments, offers data residency and ensures enterprise-grade compliance with SOC 2, HIPAA, EU AI Act and ITAR standards. Leading Fortune 1000 companies like Resmed, Siemens Healthineers, Automation Anywhere, Zscaler, Nvidia and others trust TrueFoundry to accelerate innovation and deliver AI at scale, with 10Bn + requests per month processed via its AI Gateway and more than 1000+ clusters managed by its Agentic deployment platform. TrueFoundry’s vision is to become the Central control plane for running Agentic AI at scale within enterprises and empowering it with intelligence so that the multi-agent systems become a self-sustaining ecosystem driving unparalleled speed and innovation for businesses. To learn more about TrueFoundry, visit truefoundry.com.

nOps is an automated cloud optimization platform that makes it easy to allocate and manage cloud usage, commitments, and spend. Managing $4B+ in annual cloud spend, nOps helps companies of every size, from fast-growing startups to global enterprises, reclaim millions in wasted cloud costs. Cloud waste is one of the fastest growing challenges in tech. nOps tackles it by leveraging proprietary ML modeling and AI-powered automation to guide organizations toward the right commitment strategy. The platform eliminates manual provisioning entirely, delivering maximum cost savings without sacrificing reliability, so teams can focus on building and innovating. Trusted by innovative brands around the world, nOps has been recognized as a G2 Top 50 Security Product and G2 Leader for Winter 2025, is an AWS Advanced Technology Partner, and a proud FinOps Foundation Member with our CEO serving on the FinOps Foundation Governing Board.

Hospitable, an Inc. 5000 company, gifts short-term rental hosts their valuable time back. Founded in 2016, Hospitable’s tools allow hosts to automate the most time-consuming elements of hosting. Hosts use Hospitable to answer 90% of guest messages with AI-powered automated messaging, to automate their team notifications so they never miss a clean, and to avoid double bookings with a synchronized calendar across booking channels. Hospitable allows hosts to build their own direct booking website with guest vetting, $5M damage protection, and payment processing built-in. Hospitable also connects with popular 3rd party online travel agencies such as Airbnb, Vrbo, and [Booking.com](booking.com).