Top Software Startups in North America

Citylitics delivers predictive intelligence on local utility & public infrastructure markets The U.S. needs to invest $4.5 Trillion over the next 5 years to upgrade its infrastructure, including water, energy, public transit, roads, airports, and more. Citylitics is the only source of predictive intelligence on where, how, and why these infrastructure investments will be made. Our Data Engine transforms over a billion documents buried in 31,000+ cities & utilities data sources into high value intelligence for targeted business development. The largest infrastructure industry leaders rely on Citylitics for external datasets and intelligence reports Citylitics' vision is a world where data drives Trillions of dollars of societal infrastructure investment towards the most ideal social, economic, and environmental outcomes.

Created by brothers Anton and Jerod Venema in 2008, FM has grown to over 50 employees, and 400 customers in 47 countries worldwide. Through our technology and innovation, we inspire and enable development teams through industry-leading enterprise-class real-time streaming and analytic solutions. With products built from the ground up, we live and breathe RTC technology.

PurposeMed was founded in 2019 with the mission of improving access to complex care for underserved communities. We’ve grown quickly in our first few years, and now our exceptional team serves thousands of patients each month across our multiple verticals. PurposeMed consists of three complex care business units: Freddie, Frida, and Foria, and partners with Affirming Care Pharmacy. Freddie is focused on improving sexual health through education, prevention, and treatment with a focus on the LGBTQ2S+ community—we’re the #1 rated PrEP provider in North America, serving patients in both Canada and the USA! Frida is changing the lives of patients with easier access to adult ADHD diagnosis, and fast and affordable treatment. Foria Clinic provides trans, non-binary, and gender-diverse Canadians with gender-affirming healthcare. Affirming Care Pharmacy is a specialty pharmacy with locations in Calgary, Alberta, and Mississauga, Ontario. This partnership provides our patients with an end-to-end healthcare experience, from treatment, to prescription delivery, to continuous affirming care. We’re proud to be ranked #2 on Deloitte’s 2024 list of Canada’s 50 fastest-growing tech companies and recognized as one of Canada’s Most Admired Corporate Cultures for two consecutive years. Driven by a strong mission, our team is passionate about making healthcare accessible to those who need it most—and we make sure to have fun along the way!

Whether in the world of payment, finance, fashion, art or retail, more and more companies have decided to adopt blockchain and digital assets. However, these companies are faced with a fundamental problem: how to adopt these new assets without jeopardizing their accounting processes and their “auditability”? Created in 2018 by Antoine Scalia, Cryptio is a startup that has taken on the incredible challenge of inventing the foundations of accounting and financial reporting for digital assets (crypto-currencies, NFT, digital assets). How? By offering a SaaS accounting, auditing and tax solution that bridges the gap between blockchain and accounting systems - turning data into verifiable records for accounting, treasury and tax reporting. We enable pioneering companies in the crypto ecosystem, large enterprises and financial institutions to confidently navigate the fragmented digital asset landscape. Our mission is to tackle one of the biggest challenges in crypto right now - building the infrastructure to help institutional adoption. And we're playing to win. Cyptio wants to become the source of truth in the world of crypto!

Greenspace (greenspacehealth.com) is transforming mental health systems by improving the way that care is accessed, measured and delivered. Greenspace is a growth stage technology startup with offices in Toronto and Kelowna. Since launching in 2016, the platform has been deployed across thousands of mental health practices and organizations and expanding across Canada and the US. Mental illness has passed HIV/Aids, malaria and diabetes as the leading cause of disability in the world. While there is no cure, psychotherapy is the most cost and clinically effective form of treatment. Greenspace has developed solutions that draw on technology and clinical research to improve patient outcomes within this traditional psychotherapy model. Our Measurement Platform enables mental health providers and organizations to implement consistent evidence-based measurement into their practice. Our Intake Module facilitates a more effective referral into mental health and addictions services. Our Self-Guided Module is a population health solution that provides mental health support directly to individuals in various settings. We recently helped develop and launch Wellness Together Canada (ca.portal.gs) – a major initiative funded and launched by Health Canada to provide virtual mental health and substance use support for all Canadians through COVID-19.

Kritik is an early-stage but fast growing ed-tech startup working passionately to upgrade college classroom experience with our fun and automated peer-to-peer learning technology. We launched our product into +200 universities and are ready to scale in the upcoming year. We are serial entrepreneurs, backed by some of the top players in the Canadian startup ecosystem including ApplyBoard and GarageCapital. We are looking for smart and motivated people to join the startup and be part of the fast movement in changing the way students are tasked and assessed. Recently, we launched VisibleAI (a completely new product), for which we have developed Artificial Intelligence (AI) for educators and institutions and a platform for academic integrity to equip educators with practical, ready-to-use strategies and prompts while maintaining academic integrity and fostering learning. The goal is to ensure educators are well-equipped to leverage AI, the effectiveness of PBL, and related concepts. The product offers transparency by detecting and reporting AI-generated content, helping educators maintain rigorous academic standards while embracing AI's educational potential.

nOps is an automated cloud optimization platform that makes it easy to allocate and manage cloud usage, commitments, and spend. Managing $4B+ in annual cloud spend, nOps helps companies of every size, from fast-growing startups to global enterprises, reclaim millions in wasted cloud costs. Cloud waste is one of the fastest growing challenges in tech. nOps tackles it by leveraging proprietary ML modeling and AI-powered automation to guide organizations toward the right commitment strategy. The platform eliminates manual provisioning entirely, delivering maximum cost savings without sacrificing reliability, so teams can focus on building and innovating. Trusted by innovative brands around the world, nOps has been recognized as a G2 Top 50 Security Product and G2 Leader for Winter 2025, is an AWS Advanced Technology Partner, and a proud FinOps Foundation Member with our CEO serving on the FinOps Foundation Governing Board.

At Improbable, we believe that simulations as large and complex as the real world are the next fundamental breakthrough technology. Like in the real world, objects in these simulations will change in response to their environment, and their interactions will combine to form massive, complex systems. We are building the platform to make these simulations possible. New worlds for gaming and entertainment can now be created using our product, SpatialOS. Our technology creates permanent, persistent and engaging experiences: worlds where your actions really matter. The same technology that makes imaginary worlds feel real can also illuminate complex systems at work in reality. We use insight acquired through simulation to solve real world problems. You can find out more about our technology on our website - improbable.io

Twin Health is a revolutionary Precision Health platform combining IoT Sensors, Machine Learning, and Medical Science to reverse chronic diseases like diabetes and improve human metabolic health. It was founded by experienced entrepreneurs with extensive experience building software platforms used by more than 100 million devices around the world. We are backed by Sequoia Capital, Iconiq Capital, Perceptive Advisors, Corner Ventures, LTS Investments, Helena and Sofina with $183M in Series A, Series B, and Series C funding. At Twin, we have achieved groundbreaking medical results for chronic disease reversal (12 papers published in top medical journals) using our patent-pending Whole Body Digital Twin™ technology (5 patents filed), which analyzes complex biosignals from wearable sensors, predicts metabolic outcomes using ML, and recommends highly-personalized treatments based on the metabolic profile of each patient. Our interdisciplinary team consists of engineers, scientists, and medical doctors who collaborate closely to develop these technologies and deliver exceptional health outcomes. We launched our product in 2018 with an initial focus on diabetes; doctors and coaches use our IoT- and ML-based software platform to improve the health of diabetic patients every day.

Digitally native audiences focus on speed and relevance. People have less time to learn and yet want to accomplish more. Consumers want video, case study and white paper-level content in a format that combines their effectiveness and extends their value. They need an interactive experience that moves beyond PDF limitations and that is optimized for mobile consumption. Driven by audience and consumer intelligence, we began developing a unique solution that enabled complex, in-depth content engagement beyond PDF limitations. In an HTML framework, the team developed a digital hub experience that provided the type of content found in white papers with interactive navigation tools, embedded videos, linked case studies and other connected digital content.