Top Telemedicine Startups in 2026

Spruce is a communication software platform built for independent healthcare practices. Our HIPAA-grade, cloud-based solution integrates a business phone system with texting, faxing, and telemedicine—optimizing care collaboration, streamlining patient interactions, and ensuring accountability. Trusted by tens of thousands of healthcare organizations across the U.S. and backed by over 60,000 5-star reviews, Spruce is transforming healthcare communication.

We believe learning differences are parallel ways of thinking that should be celebrated. Our mission is to provide students with the resources and encouragement to succeed in the classroom and beyond. To us, this means helping them build confidence in their unique strengths and create strategies to work around their weaknesses.

PurposeMed was founded in 2019 with the mission of improving access to complex care for underserved communities. We’ve grown quickly in our first few years, and now our exceptional team serves thousands of patients each month across our multiple verticals. PurposeMed consists of three complex care business units: Freddie, Frida, and Foria, and partners with Affirming Care Pharmacy. Freddie is focused on improving sexual health through education, prevention, and treatment with a focus on the LGBTQ2S+ community—we’re the #1 rated PrEP provider in North America, serving patients in both Canada and the USA! Frida is changing the lives of patients with easier access to adult ADHD diagnosis, and fast and affordable treatment. Foria Clinic provides trans, non-binary, and gender-diverse Canadians with gender-affirming healthcare. Affirming Care Pharmacy is a specialty pharmacy with locations in Calgary, Alberta, and Mississauga, Ontario. This partnership provides our patients with an end-to-end healthcare experience, from treatment, to prescription delivery, to continuous affirming care. We’re proud to be ranked #2 on Deloitte’s 2024 list of Canada’s 50 fastest-growing tech companies and recognized as one of Canada’s Most Admired Corporate Cultures for two consecutive years. Driven by a strong mission, our team is passionate about making healthcare accessible to those who need it most—and we make sure to have fun along the way!

Circle Medical is a venture-backed Y-Combinator healthcare startup on a mission to bring quality, delightful primary care to everyone on the planet. Built by top-tier physicians, engineers, and designers, our medical practice and underlying technology have pioneered how people find and receive care. Our focus on building directly for our patients and providers to address serious care accessibility issues has enabled us to grow over 3X year-over-year. We’re now using our most recent round of funding from WELL Health, backed by Sir Li Ka-shing, to continue building out our hybrid in-clinic and telemedicine model across all fifty states. As we enter the hypergrowth phase, we are looking for deeply motivated team players who are driven to solve some of the biggest challenges in healthcare so that people can live longer and healthier lives. More about us can be found on our website!

At TalkDoc, we understand that having a mental illness is an extremely isolating experience, where most people don't even believe you suffer from a mental illness, or downplay what that might mean in your life. Patients who suffer from severe mental illness such as psychosis often go untreated until they hit the breaking point because of this. Talkdoc provides mental healthcare to patients on Medicaid, in more than 5 counties in California, through our professional corporation partnership. TalkDoc has established itself by having the best outcomes in the entire country for Medicaid. We see mental health hospital utilization rates of 0.16% per year, as compared to 3%-4% for the general Medicaid population who sees a mental health clinician. We've helped thousands of people live healthier and happier lives. We are moving from a family business to high-growth startup, and we started that three months ago. Our technology mission is to be the safest and most private form of healthcare, that keeps patient data private long-term, while still offering the most advanced technological solutions, such as AI clinical assistants in workflows.

PicnicAI deploys AI into the real-world complexity of care delivery and clinical research. PicnicHealth helps patients navigate fragmented care with AI-powered tools backed by a clinical team, giving them a unified view of their health across all their doctors. PicnicResearch makes clinical research faster, cheaper, and more reliable, using AI agents and direct patient relationships to change the economics of drug development so that more treatments reach the patients who need them.

Mantra Health is a digital mental health clinic on a mission to improve access to evidence-based mental healthcare for young adults. Through augmenting high quality clinical services with software and design, we're on a mission to improve the mental health of over 20 million university and college students through partnerships with higher education institutions and health insurance plans.

MedMe is building the operating system for the pharmacies of the future, powering their transformation from dispensaries to community healthcare hubs. Hi, I’m Rui and I’m the Co-Founder and Chief Clinical Officer of MedMe. I’m a pharmacist, and despite a $200k Doctor of Pharmacy degree, I still spend most of my time writing notes by hand and fielding phone calls for refills. When in fact, pharmacists can directly prescribe meds (like birth control), adjust diabetes/heart medications, give over 20 different vaccines/injections, and much more! I was almost ready to leave my profession when I met my co-founders Purya & Nick. Purya was a health data scientist for the government and Nick a product engineer for the Tesla Roadster. They’d watched their own parents struggle with managing 10+ medications and were equally passionate about using pharmacists to provide more services for patients in the community. Together, we identified the biggest problem to be existing pharmacy software built 20 years ago with the primary purpose to sell drugs. So, we built MedMe. Our mission is to build an all-in-one cloud-based platform that empowers pharmacists to schedule, document, and manage clinical services at scale. Our clients include the 2 largest pharmacy chains in Canada, servicing 3500+ pharmacies, and powering over ~20M patient services, including playing a critical role across the country throughout the pandemic. We have raised over $3.7M USD to date including from M12 (Microsoft’s Venture Fund), MaRS IAF, and Y-Combinator. We're building on our rapid growth and role throughout the pandemic to take our modular platform to the next level; providing community pharmacies of all sizes and geographies the transformative technology to service high-quality care experiences and accessible healthcare offerings to their patients.

At Ophelia, the users we build products for wear as many hats as we do. We build products for our patients to connect with Ophelia and their providers, for our team members to better understand our data, and for our clinicians to provide high quality care to our patients. We’ve built a state of the art, proprietary electronic health record for our team to provide tailored treatment to each of their patients, that we’re constantly improving to make our clinicians lives easier, and our patients lives better. One of the most important ways we do this is with our data, and we work to aggregate it from all our sources to help the team draw brand new insights from it.

First, stop googling your symptoms! K is a new kind of healthcare app that gives everyone free, personalized health information based on the experiences of People Like You. It only takes a minute to check how people like you were diagnosed and treated by doctors when they were in your situation. Then you can make an informed decision about what to do next. Then, get a doctor’s opinion through the app. This isn’t your typical telemedicine visit. Share your K results with a board-certified doctor affiliated with K Health, who will pick up where K left off. You don’t have to repeat yourself, and you’ll have not only the doctor’s experience but also the experiences of People Like You to guide you both toward a truly personalized care plan you can trust. The doctor can diagnose, prescribe medication, and advise you within minutes. Our affiliated doctors are board-certified ER or primary care doctors, employed by or contracted with an affiliated physician-owned professional corporation.