Top Tech Startups in San Francisco, CA in 2027

Actively transforms revenue teams from human-led execution to Intelligence-Led Revenue — a new way of running revenue where AI agents do the work humans cannot sustain at scale. Its platform deploys one dedicated agent per account, working 24/7 in the background to research, identify opportunities, and advance next steps without being asked. Founded by former Stanford AI researchers, Actively is backed by top investors, including TCV, First Harmonic, and Bain Capital Ventures. To learn more, visit actively.ai.

Kick Health helps smart, capable professionals overcome the fears that hold them back from being the very best versions of themselves. Our personalized telemedicine service offers easy access to sleep medicine and beta-blocker prescriptions, the insider's edge to blocking nervous symptoms like racing heartbeat, shaky hands, or trembly voice. Kick is partnered with leading experts from Stanford, Yale, and Harvard in psychiatry, medicine, and emotional fitness.

marco provides collateral-free, working capital from SME exporter trade receivables. Platform by marco provides a seamless digital process to upload your documents and invoices and receive faster, friendlier, financing.

Hallak & Co. is the company behind O.S.C.A.R.™ Proprietary Operational Execution Infrastructure. O.S.C.A.R.™ establishes ownership, accountability, decision structure, KPIs, reporting and leadership cadence across organizations as growth, AI, automation and new ways of working increase operational complexity. Developed from nearly three decades of firsthand business-building and operating experience, O.S.C.A.R.™ is designed to strengthen how organizations execute across teams. Hallak & Co. is expanding O.S.C.A.R.™ through client organizations and a network of experienced Independent Executives, while building the foundation for a future O.S.C.A.R.™ SaaS platform.

Effective AI is on a mission to transform the future of work by building AI that tackles complex knowledge tasks. Founded by Abhay Mitra (ex-CTO at Nirvana Insurance) and Kunal Singhal (ex-Meta, Grammarly, and Founding Engineer at Wisdom AI), we’re a small, passionate team based in San Francisco that thrives on collaboration, curiosity, and bold problem-solving. Our culture values ownership, continuous learning, and transparency, giving every team member a chance to make a meaningful impact from day one.

The architectures that power modern AI were designed for language, not for science. They were never built to understand DNA, interpret experiments, or learn the rules that govern living systems. Closing this gap represents one of the defining opportunities of our time. Our team has pioneered advances across frontier AI, including the first models trained with one-million-token context windows, and now scaling toward one billion. We focus on innovations on systems and architecture, because building AI for science demands a fundamentally different foundation. As a first application of this technology engine, we are advancing AI for life, the most complex and consequential domain of all. We are the AI team behind Evo and Evo 2, the generative genomics models used to create real gene-editing tools and the first whole genomes designed entirely by AI. That work demonstrated that AI can create biology, not just analyze it. We are now building multimodal models trained directly on the fabric of biology, enabling faster discovery, deeper understanding, and entirely new capabilities. As we push the frontier of scientific world models, we will build systems hand-in-hand to ensure global biological resilience: rapid detection, rapid response, and rapid countermeasures against emerging threats, both natural and synthetic. Our mission is ambitious: to reimagine what AI can do for science, and to build that future.

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