Top Tech Startups in San Francisco, CA in 2027

Firecrawl is the easiest way to turn the web into data AI agents can use. One API call converts any URL into clean, LLM-ready markdown or structured data - the boring-hard problem everyone building with LLMs eventually hits, solved. We hit 8 figures in ARR in year one and more than doubled it in year two. We have 150k+ GitHub stars, and developers, agents, and category-defining AI companies build on us every day. Growth like this is rare, and we're just getting started. We're a small team punching far above our weight. Everyone here owns a real piece of the product and company, end to end, and runs it themselves - no hiding behind process or headcount. This is a place for people who want to work at the frontier: an AI company building the infrastructure other AI companies run on, not one bolting AI onto an existing product. We move fast, go deep, and are building the tools superintelligence will rely on to gather data from the web.

Post-human ideas that once belonged to science fiction are becoming material reality, embedded into technical systems through AI, robotics, biotechnology and new forms of computation. Yaya Labs is a technology studio born from science fiction. It started with a humanoid robot: a vector for experimentation that led to our first personality protocol, an embodied AI persona trained on ethics, memory, aesthetics and emotional grounding, and road-tested at cultural events around the world. From there, we began exploring what happens when human wetware, artificial intelligence and machine systems begin to converge. Today, Yaya Labs operates at the conceptual edge of human-machine relations, developing new interfaces between biology, technology and culture. We explore AI personality protocols, embodied intelligence, brain-computer interfaces and systems that challenge the boundaries of individual agency. The next phase of AI isn't simply about making machines more intelligent. It's about what happens when intelligence becomes embodied, networked and alive.

At Snout, our mission is to ensure no one ever has to make a healthcare decision for their pet based on the money in their bank account. As a modern financing alternative to traditional pet insurance, Snout wellness plans cover 100% of routine veterinary care like vaccinations, unlimited visits, and other valuable member benefits — designed to be used, not forgotten. We help pet owners prioritize care while removing financial risk for veterinary practices.

Evonaire is a Delaware Public Benefit Corporation building foundational infrastructure for the emotional web. Our platform combines voice-first experiences, ethical AI, creator licensing, and privacy-first technology to help people safely create, share, and protect emotional knowledge. We are developing proprietary systems including UPstream™ Licensing, ClaimChain™, GAIA™, and consent-based creator tools designed for the next generation of emotional intellectual property. Our mission is to make emotional creativity ownable, licensable, and protected while advancing accessibility, privacy, and human dignity.

Help teams get more from every token. We're building the control layer for how modern teams use AI. Come help us make that work more visible, efficient, and secure. Join an early-stage startup built on high ownership, fast iteration, and entrepreneurial kindness. You’ll work closely with repeat founders and an extraordinary founding team to launch an innovative AI tool that both engineering and finance teams love, in a collaborative and generous environment with great people, food, and conversations.

Alhena AI (formerly known as Gleen AI) is an all-in-one conversational e-commerce AI concierge designed to turn customer experience into revenue. Founded by ex-LinkedIn engineers, it orchestrates multiple specialized, vertical models rather than relying on a single generic LLM to ensure 100% hallucination-free, brand-aligned interactions across the entire buyer journey

The money layer for agentic economy. AI agents act. Noesia makes them pay. AI agents can research, compare, write code and run entire workflows. Then they stop and ask a human for a credit card. Noesia gives every AI agent a financial identity one authority that decides every transaction across every rail, and adjudicates what happens when it goes wrong

Lunar is a stealth hospital technology company building a new type of software platform for hospitals. Built on a foundation of two years of research and development, the Lunar cloud platform brings state-of-the-art technology to solve some of the most frustrating challenges faced by hospitals today. The company focuses on using smarter automation, better data, and sensible machine learning to empower hospitals with the tools to provide more precise and effective care, doing things they can't today. This next-generation platform is a fundamental rebuild of the information infrastructure that runs health systems. All of it – from doctors, nurses, pharmacists, lab technicians, coders, billers, supply chain, and even patients – Lunar’s software powers everything, soup-to-nuts. We believe that this mission is the moon landing of healthcare – something so consequential and ambitious that most people believe it to be impossible. Backed by Silicon Valley’s preeminent venture capital firms, we believe in the power of a small, high performance team of seasoned professionals operating at the peak of their abilities. We value people who are driven, curious, have sound judgement, and care about doing the best work of their careers.

Metriport is an open-source platform that makes it easy for healthcare organizations to access and exchange medical data for their patients.