Top Tech Startups in Indiana, US in 2026

Iterative Health is pioneering the use of artificial intelligence-based precision medicine in gastroenterology (GI), with the aim of helping to optimize clinical trials investigating treatment of inflammatory bowel disease (IBD). We use advanced machine learning and computer vision to interpret endoscopic images along with other types of data, helping clinicians to better assess patients with potential GI problems. This gives practitioners enhanced capabilities in the detection, annotation, disease scoring and treatment of GI related diseases. Iterative Health is initially applying these advances towards standardizing disease severity characterization for inflammatory bowel disease. Ultimately, the company aims to establish more meaningful endpoints to serve as better predictors of both therapeutic response and disease outcomes. The company is headquartered in Cambridge, Massachusetts.

Machinio.com is one of the world’s largest platforms connecting buyers and sellers of inventory and related services across multiple industries. Founded in 2013 and acquired in 2018, Machinio now serves over 4,000 paying clients globally and continues to expand its reach and impact. Thousands of dealers and suppliers rely on the platform to market and sell their equipment, connecting them with millions of prospective buyers each year. Machinio is widely recognized for leveraging technology to simplify and modernize the buying and selling process. By introducing innovative tools and improving marketplace efficiency, the company has helped both buyers and sellers save significant time while facilitating high-value transactions worldwide. Machinio System is Machinio’s all-in-one software solution built specifically for dealers and service providers. Launched in 2018, it combines modern, fully customizable, SEO-optimized websites with a fully integrated CRM platform for dealers. This unified solution enables businesses to manage their entire workflow in one place — including inventory, lead management, quoting, invoicing, contact databases, email marketing campaigns, and more. With continuous feature development and a strong product roadmap, Machinio System empowers dealers and service providers to maintain a professional online presence, leverage intelligent sales and marketing tools, and consistently generate and nurture business opportunities. Machinio has been featured in leading media outlets including Forbes, Business Insider, Inc., EquipmentWorld, Agriculture.com, and others.

Bytenestus is a trusted software engineering and IT solutions company committed to helping businesses accelerate their digital transformation. We deliver innovative, scalable, and secure technology solutions tailored to meet the unique needs of startups, enterprises, and organizations worldwide.

Here at MegaCorp, we work with customers from all industries with different shipping needs. Some of our clients ship one truckload a month, others ship hundreds of truckloads a week. We have the feel of a family-owned company (we are family-owned and consider our team the MegaFamily!) with the resources of a large corporation. Our unique Corp model has a small team of people working on your account so there is always someone available that is well-versed in your shipping needs and requirements. We have been chosen to work with many Fortune 500 companies and named as a Top 30 Logistics Provider.

SEP is a software product and design company that builds products for global, midsize and small companies. Started in 1988 and headquartered in Westfield, Indiana, SEP was created by four Rose-Hulman Institute of Technology graduates. SEP is one of Indiana’s largest software development firms with more than 180 employees. SEP partners with companies to develop software products and information systems that solve complex problems and building products that impact people’s lives. SEP serves Fortune and Global 1000 clients as well as mid-sized and startup companies.

Your idea deserves a shot! We will help you realize the project you have had in mind all this time. Without hurting your pocket.

At Deccan AI, we operate at the intersection of humans and AI, enabling groundbreaking use cases in the Generative AI space - powering some of the world’s best models and AI teams in the world. Our AI enabled services across various industries help organizations automate complex processes and elevate customer experiences by blending a talented workforce with custom AI solutions. We also help organizations scale faster by leveraging our top talent across Machine Learning, Software Development, and beyond. At Deccan AI, we don’t just build solutions—we empower innovation, accelerate growth, and shape the future of AI.