Top B2B Startups in 2027

AVNO is an AI technology company building intelligent phone automation solutions for service businesses, starting with the roofing industry. Our mission is simple: help businesses capture every opportunity, deliver exceptional customer experiences, and operate more efficiently. AVNO’s AI-powered phone receptionists answer calls 24/7, qualify potential customers, schedule estimates and inspections, and handle urgent inquiries. By automating these essential interactions, we help business owners spend less time managing calls and more time growing their companies. We’re building AVNO with a long-term vision of making intelligent customer communication accessible to businesses of all sizes. As an early-stage company, we’re focused on developing a strong product, delivering measurable value to customers, and building a team of ambitious people who want to help shape our growth. We’re currently expanding our sales organization and looking for independent, results-driven professionals who want to grow alongside AVNO.

TP53 is a bootstrapped Italian software house building AI products for healthcare professionals. Cibus is the AI CRM for nutritionists and dietitians. Writing a meal plan used to take hours: gram by gram, food by food, balancing every macro by hand. Cibus writes the plan in minutes, following the nutritionist's own method, with the numbers already balanced. It also handles patients, appointments, documents and invoicing in one place. Scriva is an AI clinical scribe: it listens to the visit and writes the clinical notes, so doctors and therapists can focus on the patient instead of the keyboard. We're growing across Italy and now expanding into Spain. Small team, high pace, no investors telling us what to do: we build what our customers actually need.

Untapped Solutions is a venture-backed SaaS company building AI-powered CRM and outcomes technology for nonprofits, correctional facilities, and government agencies serving justice-impacted and underserved communities. Traditional case management systems are fragmented, manual, and built for tracking—not outcomes. We’re changing that by combining modern CRM infrastructure with AI-assisted workflows that automate referrals, surface real-time opportunities, and help frontline staff move clients into jobs, housing, healthcare, and training faster. Our platform integrates with existing systems (including Salesforce) rather than replacing them, allowing organizations to modernize without disruption. Clients and staff use web and mobile tools to manage referrals, access resources, and track progress in real time. We are backed by Google, Dream.Org, and Robin Hood Foundation, and have been featured in CNN, PBS, and the Financial Times. Today, Untapped Solutions partners with over 100 organizations nationally and supports a growing network of job seekers and service participants. We are a mission-driven but revenue-focused company. We move fast, operate with ownership, and expect our team to build, test, and improve in real-world conditions. Early hires at Untapped shape how the company grows.

Every patient deserves fast access to life-changing medications. At Sodalis, we're building the AI operating system for specialty pharmacy—turning weeks of manual coordination into minutes of intelligent automation. We're serving tens of thousands of patients today, scaling to hundreds of thousands. Backed by Gradient Ventures. Founded by veterans from Apple's Applied ML, Included Health, and Avella Specialty Pharmacy (scaled to $1.5B+ before acquisition by OptumRx).

We focus on solving the hardest, most overlooked problems for the enterprises that depend on them. Supply chains have always been volatile, but the last few years have shattered any illusion of stability. Three ‘once-in-a-lifetime’ supply chain shocks—COVID-19, war in Europe, and tariffs—have tested even the most resilient operations. Most enterprises have hundreds of employees dealing with suppliers at different operational levels. Making analysts sift through siloed data and thousands of contracts is neither feasible nor economically viable. Companies must act fast to seize value to stay competitive. Humans alone simply can’t keep pace. Our first wave of Mages focuses on just this. Mages join teams as employees, executing work end-to-end to deliver savings on the back of the data transformation work that companies have worked hard on.