Top Tech Startups in United States in 2026

Cypris is the vertical AI platform for corporate R&D and innovation teams. We centralize scientific papers, patents, market news, and company intelligence into a single platform with over 500M+ global data points. On top of this foundation, we’re building AI Agents tailored to R&D workflows, powered by the latest models from OpenAI, Anthropic, and others. With Cypris, teams can manage projects, automate research workflows, and track markets, competitors, and technologies to accelerate product development and R&D strategy. Today, leading mid-size to Fortune 100 companies in aerospace, genomics, cancer research, and autonomous systems rely on Cypris to innovate faster and with more clarity. Customers include the US Airforce, NASA, J&J, Yamaha and more.

Accounting and Payroll Software as a Service (SaaS) for American small business owners with 1 to 100 employees.

Kargo is the leader in mobile brand advertising. Bringing together creativity, technology and quality, Kargo empowers advertisers to break convention and build connections with consumers on the most important screen today—the phone. Through their high-end editorial alliance composed of world-class publisher partners, as well as their proprietary advertising automation tools and award-winning creative studio, we enable brands and agencies to reach eight out of 10 smartphone users in the US with memorable, measurable mobile ad experiences. In 2015, Kargo was recognized by Crain's NY Business as one of the 50 fastest growing companies in New York and by Inc. as one of the 500 fastest-growing companies in the US. Business Insider also ranked Kargo one of the “hottest pre-IPO ad tech startups” in both 2015 and 2016. Kargo employs more than 200 people in New York, Chicago, Dallas, San Francisco, Los Angeles and London.

Arize AI was started by building on an insight from our own experiences as data scientists, engineers and product leaders. We are a team of people extremely passionate about the potential of AI and Machine Learning. We're building the platform to watch, troubleshoot, explain and provide guardrails on AI, as it is deployed into the real world. Check out some articles about Arize! 1. Techcrunch Launch: techcrunch.com/2020/02/18/tubemogul-execs-launch-arize-ai-for-ai-troublehsooting 2. Why We Exist: medium.com/@arizeai/why-we-exist-df95d90dcf7e 3. Why our VCs backed us: medium.com/trinity-ventures/why-we-invested-in-arize-ai-repeat-trinity-entrep…

DataForce by TransPerfect is part of the TransPerfect family of companies, the world’s largest provider of language and technology solutions for global business, with offices in more than 100 cities worldwide. We offer high-quality data for Human-Machine Interaction to some of the most prestigious technology companies in the world. Our division focuses on gathering, enriching and processing data for Machine Learning in different AI domains. To learn more about DataForce please visit us at transperfect.com/dataforce

Untapped Ventures is an early-stage VC firm backing technical AI founders building the next generation of AI-Native B2B startups - from Agentic AI and Vertical AI to AI Infrastructure. We lead, co-lead, and follow Pre-Seed and Seed rounds with $500K-$2M checks for AI startups with a focus on Native AI, Frontier AI, Embodied AI, Deep Tech AI, and AI Convergence. Our mission is to help transform the lives of 1 billion people through technology by combining early capital with hands-on growth expertise and access to a powerful network of advisors, operators, and investors.

Trial Library is an AI-native platform that matches cancer patients to clinical trials at the point of care. We connect patients, providers, and biopharma sponsors by making trial access faster, simpler, and built into routine care. Our team guides patients through the trial lifecycle while providers stay in the loop and patients stay in their care.

Mood Health believes that high-quality mental health care must be accessible to those who need it most. Our mission is to reduce misdiagnosis, increase affordability, and ensure that patients are matched with the type of treatment they need. We're taking the challenges of the current US healthcare system head-on, working our way through some of the most complex problems with our mission as a north star.

We founded Standard Bots because we believe that automation can lead to a better world. By performing time-consuming, repetitive, and dangerous tasks, robotics gives us more time to be creative, spend time with loved ones, and chase our dreams. Though the potential of this technology is immense, when we looked around we saw a broken robotics market — one with enormous upfront costs, excessively complex software, and outdated support systems that make it impossible for many business to take advantage of automation’s vast benefits. So we assembled a team of experts to build a new robot, write custom software for it, and develop a new kind of subscription model that opens the world of automation to everyone. Expanding access to robotics doesn’t end when our customers receive their product either. We are committed to offering the best ongoing support to keep every RO1 operating at the cutting edge. Automation will define our future, so it must be widely available and applied toward a noble mission. We’ve taken the first step, and we’re just getting started.