Top Tech Startups in San Francisco, CA in 2027

Galvix's core platform streamlines the sales tax compliance process, empowering SaaS companies to stay fully compliant while saving valuable time and resources. Galvix automates everything from sales tax calculations to filing returns, ensuring accurate and timely compliance with state and country-specific tax laws. By leveraging cutting-edge technology, we provide a comprehensive solution that helps businesses avoid penalties, mitigate risks, and focus on their core operations.

CROSSK is building Whitebrinjal — an AI-driven decision infrastructure for complex enterprise technology procurement. Enterprises struggle to evaluate emerging technologies because the hardest work happens before procurement: defining the problem, aligning stakeholders, comparing unfamiliar solutions, validating fit, and building the business case. Whitebrinjal structures this fragmented pre-procurement journey into a decision layer—helping enterprises move from complex problems to decision-ready engagement with the right technology providers, while helping providers reach qualified enterprise opportunities with context, intent, and stakeholder alignment. We are solving the gap between “we have a complex problem” and “we know what to buy, why, and from whom.”

PhrasIQ is building decision infrastructure for enterprise finance. Enterprises have invested heavily in Systems of Record to store data, Systems of Analytics to understand data, and increasingly Systems of Intelligence to generate answers. Yet critical business decisions remain slow because finance teams must reconcile fragmented data, validate assumptions, investigate variances, and defend their reasoning before action can be taken. We call this decision latency. Our core belief is that trust, not AI capability, is the primary bottleneck in enterprise decision-making. Rather than applying AI directly to fragmented enterprise data, PhrasIQ establishes structured truth first through deterministic reconciliation, lineage tracking, governance, and auditability. On this trusted foundation, our decision intelligence platform delivers explainable forecasts, variance analysis, anomaly detection, and decision recommendations. Beyond helping teams make faster decisions, PhrasIQ captures the assumptions, reasoning, decisions, outcomes, and learnings behind every decision, transforming them into persistent organizational decision intelligence. We believe this represents the next foundational enterprise software category: Systems of Decision. We are initially focused on enterprise finance, where trust, accountability, and auditability are mission-critical, with a long-term vision of becoming the decision infrastructure layer for modern enterprises.

We aggregate federal and state geospatial datasets and regulatory documents and build AI systems to give project developers and contractors automated spatial intelligence from site selection to permitting to project development across carbon sequestration, geothermal, hydrogen, and minerals projects.

Aptos is building a Layer 1 blockchain designed with an emphasis on absolute safety, extensible scalability, and credible neutrality — values that we know firsthand and viscerally understand. Now, on the fourth iteration of the consensus protocol, we are confident that Aptos is capable of bringing affordability, decentralization, and speed to the daily lives of billions of internet users. It is the lowest latency, optimistically-responsive BFT protocol available, and it features a robust, on-chain reputation system and novel methods for parallel execution — a key enabler of speed at scale. We will rapidly deploy many key innovations in performance, functionality and improvements to the overall user experience and leverage our ability to do major upgrades seamlessly in the process.

At Toi Labs, we’re pioneering the next frontier of personal health monitoring—starting in the most unexpected place: the bathroom. By transforming the toilet into a passive health companion, we deliver real-time, actionable insights into gut health and more—without requiring users to change their behavior. Our platform enables early detection and preventive care right from the home. Recognized by TIME as a Best Invention of the Year and backed by TOTO, Sloan and the NIH, we’re combining elegant design, embedded technology, and data science to redefine how—and where—healthcare happens.

Our mission is to build the world's last hedge fund - autonomously run by a decentralized network of data, intelligence, and capital. youtube.com/watch?v=dhJnt0N497c youtube.com/watch?v=GWeC2PK4yXQ

MoodMe is an innovative B2B tech leader on a mission to revolutionize the way businesses engage and gain insights through AIaaS and enterprise agreements. By leveraging the power of Face AI technologies, we create experiences that are not just engaging but profoundly insightful, providing a window into the hearts and minds of the target audience. Our vision is to set the standard in empathetic engagement, where user-centric experiences boost customer satisfaction, foster loyalty, and drive outstanding performance across diverse industries. At our core, we are dedicated to uniting innovation and ethics to craft an AI landscape that is unbiased and empathetic, ultimately making a powerful positive impact on a global scale. And this is only the beginning!

TrueFoundry is an Enterprise Platform as a service that enables companies to build, ship and govern Agentic AI applications securely, at scale and with reliability through its AI Gateway and Agentic Deployment platform. Its AI Gateway encompasses a combination of - LLM Gateway, MCP Gateway and Agent Gateway - enabling enterprises to manage, observe, and govern access to all components of a Gen AI Application from a single control plane while ensuring proper FinOps controls. Its Agentic Deployment platform enables organizations to deploy models on GPUs using best practices, run and scale AI agents, and host MCP servers - all within the same Kubernetes-native platform. It supports on-premise, multi-cloud or Hybrid installation for both the AI Gateway and deployment environments, offers data residency and ensures enterprise-grade compliance with SOC 2, HIPAA, EU AI Act and ITAR standards. Leading Fortune 1000 companies like Resmed, Siemens Healthineers, Automation Anywhere, Zscaler, Nvidia and others trust TrueFoundry to accelerate innovation and deliver AI at scale, with 10Bn + requests per month processed via its AI Gateway and more than 1000+ clusters managed by its Agentic deployment platform. TrueFoundry’s vision is to become the Central control plane for running Agentic AI at scale within enterprises and empowering it with intelligence so that the multi-agent systems become a self-sustaining ecosystem driving unparalleled speed and innovation for businesses. To learn more about TrueFoundry, visit truefoundry.com.

nOps is an automated cloud optimization platform that makes it easy to allocate and manage cloud usage, commitments, and spend. Managing $4B+ in annual cloud spend, nOps helps companies of every size, from fast-growing startups to global enterprises, reclaim millions in wasted cloud costs. Cloud waste is one of the fastest growing challenges in tech. nOps tackles it by leveraging proprietary ML modeling and AI-powered automation to guide organizations toward the right commitment strategy. The platform eliminates manual provisioning entirely, delivering maximum cost savings without sacrificing reliability, so teams can focus on building and innovating. Trusted by innovative brands around the world, nOps has been recognized as a G2 Top 50 Security Product and G2 Leader for Winter 2025, is an AWS Advanced Technology Partner, and a proud FinOps Foundation Member with our CEO serving on the FinOps Foundation Governing Board.