Top Software Startups in 2027

At American Well, we believe digital care delivery will transform healthcare. Our mission is to connect and enable providers, insurers, patients, and innovators to deliver greater access to more affordable, higher quality care. We do this by partnering with our clients to deliver video visits over mobile and web. We have doctors, therapists, and specialists on staff to help people get care when and where they need it most.

We are not just an ad agency or a creative agency, we are a Communication Company. Definitions are limiting (and boring). Just releasing ourselves from the shackles of these preset definitions, we are left in a world full of possibilities. Our creative minds are unleashed. And this lets us take up challenges without fearing limitations. Moshi Moshi is a young, creative, gutsy, and committed communication company that wants its clients to always Expect the EXTRA from it. The company was founded in 2014 by two young, passionate individuals in their 20’s, while they were still pursuing their second year from Christ College, Bangalore. Backed by a strong fundamental/ value system, and experience of working with over 1000+ brands, a huge team of creative folks, marketers, learners, developers, coders, and a puppy momo, Moshi Moshi is an experience rather than a company.

At Merito, we’re building a decision making + financing platform for D2C brands. 600+ D2C brands use Merito, in just a year of our launch (with >75% inbound!). 100,000 brands will be on Merito in the next 3 years, from around the globe. We’re building a unique business model supported by a strong product moat. We’re backed by marquee angel investors, large family offices and micro VCs. We’ve achieved this with a hungry team of 10, and are now expanding our team to take Merito to the next level. Email us on [email protected] to find out more!

EngagedMD is a fast-growing B2B software company that has developed the leading patient journey management solution for the fast-growing fertility sector. Nearly half of fertility patients in the US use our eLearn and eSign tools. Clinics use our software to reduce repetitive, manual tasks and streamline the patient journey, which helps them increase capacity and growth while improving the patient experience and reducing doctor and staff burnout. We are known for having a collaborative, friendly, high energy and fast-moving culture and a focused, start-up atmosphere.

Fullscript is a disruptive healthcare technology and service company. Our portfolio brings together the best nutritional supplement wholesale business with the premier online supplement dispensing platform. We provide innovative solutions for integrative practitioners and patients who seek a personalized experience and a holistic approach to healthcare. In the summer of 2018, Natural Partners, a national player in wholesale supplement distribution, merged with Fullscript, the creators of the first online supplement dispensing platform, to create Natural Partners Fullscript. Since then, NPFS has been the preferred partner of over 300+ professional supplement brands, EHRs such as Power2Practice and Jane, and major influencers in integrative health including Dr. Josh Axe and Dr. Aviva Romm.

About us We're a University of Oxford spinout on a mission to make accurate 3D avatars available to everyone with a smartphone. We're supported by world-leading innovation partners such as the University of Oxford, Innovate UK and Digital Catapult. We're a diverse group of business people, engineers, scientists, and developers on a mission to disrupt and improve how everyone shops for clothes, tracks their fitness and health goals We offer: - An agile friendly team that values diversity, ideas, actions and contributions from day one - Personalised and flexible working - Opportunity to join a low ego, high ambition startup working on interesting and challenging technology and business problems - Accelerated learning & development with world leading academics, innovators and innovation partners - A personalised benefits package with equity options and ownership alongside a competitive salary Join and help us build the next-gen 3D avatars for everyone!

Levelpath is the AI-native procurement platform transforming how global enterprises manage indirect spend. Built from the ground up for the AI era, our platform unifies procurement operations through intelligent automation, featuring an intuitive stakeholder interface, advanced workflow orchestration, and our proprietary Hyperbridge reasoning engine that delivers real-time intelligence and complete visibility across all procurement activities. Trusted by leading Fortune enterprises worldwide, including Ace Hardware, Amgen, Coupang, Fortrea, GATX, SiriusXM, SSM Health, and Western Union, Levelpath's AI-native architecture enables organizations to collaborate smarter, operate faster, and scale procurement operations that drive measurable business value. Headquartered in San Francisco, Levelpath is backed by Benchmark, Redpoint Ventures, Menlo Ventures, NewView Capital, and World Innovation Lab.

With Craftwork, homeowners will get an instant quote for whatever they need painted simply by answering a few questions and using the camera on their phone to measure the surface area of the space. They will then make a deposit and schedule their project for a time that works for them, all without ever needing to speak with another human.

As passionate scientists and engineers, we are well aware of the plethora of critical problems in the world that cannot be solved because humanity simply does not have enough computing power. To address this, Vorticity is developing a radically new silicon chip architecture and system to dramatically accelerate scientific computing problems. Vorticity’s mission is to expand human ingenuity. To do that we are building a team of exceptional people to work together on big problems. Join us!

Parker is the AI creative director built to produce the highest-performing ads on the internet. Every company needs to grow. That's not new. What is new is that AI is about to create more companies than the world has ever seen, and every single one of them will eventually need to find customers. That problem isn't going anywhere. If anything, it's getting bigger. There are thousands of ad agencies built to solve it. A handful are great. Most are honestly pretty bad. And none of them scale past the people who work there. The idea behind Parker is simple: what if there's one agency that's as good as the best in the world, except it runs in software instead of people? We launched. We went viral. We've grown 10x since January. Top brands like LiquidIV, Gruns, and Legends now rely on Parker to create ads that actually win. We're not building just another AI tool. We're building the default answer to the question every company eventually asks: who's going to help us grow? We're a small team of people who deeply love their craft. Engineers who love to build, creative strategists who live for a great ad, and marketers obsessed with growth. We don't just work on this. We love what we're working on. If that sounds like you, we'd like to meet you.