Top Health Care Information Technology Startups in 2026

Twin Health is a revolutionary Precision Health platform combining IoT Sensors, Machine Learning, and Medical Science to reverse chronic diseases like diabetes and improve human metabolic health. It was founded by experienced entrepreneurs with extensive experience building software platforms used by more than 100 million devices around the world. We are backed by Sequoia Capital, Iconiq Capital, Perceptive Advisors, Corner Ventures, LTS Investments, Helena and Sofina with $183M in Series A, Series B, and Series C funding. At Twin, we have achieved groundbreaking medical results for chronic disease reversal (12 papers published in top medical journals) using our patent-pending Whole Body Digital Twin™ technology (5 patents filed), which analyzes complex biosignals from wearable sensors, predicts metabolic outcomes using ML, and recommends highly-personalized treatments based on the metabolic profile of each patient. Our interdisciplinary team consists of engineers, scientists, and medical doctors who collaborate closely to develop these technologies and deliver exceptional health outcomes. We launched our product in 2018 with an initial focus on diabetes; doctors and coaches use our IoT- and ML-based software platform to improve the health of diabetic patients every day.

Avant-garde Health enables hospitals and clinicians to identify and pursue opportunities for delivering the highest quality and most cost effective care. We launched in the spring of 2015 and we are working with over a dozen hospitals, including many of the leading hospitals the country. Our main product is our web-based analytics platform that allow hospitals and physicians to deeply analyze and compare their costs and outcomes in care delivery. We were recently profiled by the Huffington Post huff.to/1QjUKRL Avant-garde Health grows out of the value-based health care delivery work at Harvard Business School that is led by Professors Michael Porter and Bob Kaplan, who are our among advisers. In the 1.5 years since being founded we have authored 6 Harvard Business Review articles related to our work.

Recent Awards / Mentions: - Apple's Top 10 Apps in the World - Business Insider's most innovative companies in the world along with Uber and Snapchat: At Lark, we’re on a mission to improve people’s health and happiness through our digital health coach AI which has become the first A.I. nurse to be reimbursed as a live healthcare professional. Our app takes data from phones and wearables, and uses it to create a personalized health "chat bot" buddy that sticks with users and helps them stay active, sleep more, and eat healthy. We are using NLP to process millions of meals, and accelerometer data to compute activity and sleep amounts from users' phones. Our chat AI is the most sophisticated digital health engagement tool in the world. Join us and make it even better!

Our technology-enabled community care approach helps us to bring evidence-based interventions and value-based care to Medicaid patients and providers. When we looked at the universe of effective interventions for improving outcomes in Medicaid, we saw very little overlap with what is covered by fee-for-service healthcare payment systems. In contrast, the Waymark team will earn payment based on how well we keep patients healthy – not based on how many patients visit our office each day, or how many tests and procedures we perform. Nothing simplifies a business model quite like this does. When we improve outcomes for our patients, our business works. When we do not, we fail. We are building an inclusive company. We design our products and our service delivery specifically for communities that have been historically excluded, because of language, race, poverty, substance use, or sexual identity.

Circle Medical is a venture-backed Y-Combinator healthcare startup on a mission to bring quality, delightful primary care to everyone on the planet. Built by top-tier physicians, engineers, and designers, our medical practice and underlying technology have pioneered how people find and receive care. Our focus on building directly for our patients and providers to address serious care accessibility issues has enabled us to grow over 3X year-over-year. We’re now using our most recent round of funding from WELL Health, backed by Sir Li Ka-shing, to continue building out our hybrid in-clinic and telemedicine model across all fifty states. As we enter the hypergrowth phase, we are looking for deeply motivated team players who are driven to solve some of the biggest challenges in healthcare so that people can live longer and healthier lives. More about us can be found on our website!

Imagine a mood tracker, mindfulness coach, anxiety helper, and mood-boosting buddy, all rolled into one. Used by more than 1 million people from more than 30 countries - and a top app recommended by the NHS UK - Wysa is one of the global leaders in this space. Wysa, your happiness buddy, is that friendly and caring chatbot. In addition, when things get too much, get access to digital self-help tools through your own personal library; or speak to a trained psychologist who is there to offer coaching support when you need help. Always there for you when you need someone to talk to, the Wysa platform helps you keep track of your mood with friendly chats and helps fight stress and anxiety with its proven chat-based self-help techniques and calming meditation and mindfulness audios. Checking in with Wysa regularly will improve your emotional health so you can track your happiness and mood.

DocNetwork is the leading electronic health record system for camps, child care and schools. Our mission is to bring the lightweight side of the medical industry onto the web. Our team is accomplishing incredible things. We’re an ambitious group, and are looking for people who can solve challenging problems, make a real impact, and help us build something big!

Doctolib is the largest e-health service in Europe Our mission is to contribute to improving our healthcare systems in partnership with healthcare professionals. We aim at creating the largest community of healthcare providers in the world and build with them the practices and hospitals of the future. We believe that it's the best way to improve patient experience and people health. 115,000 Practitioners use Doctolib every day 50 million Patient visits every month on Doctolib 1,250 Doctolibers work hard every day We offer two solutions For healthcare providers - A new generation of software to transform patient and consultation management. For patients - A comprehensive online service to improve their patient experience in healthcare. We have strong commitments towards our users - Doctolib is committed to protecting user data and respects healthcare ethics and regulations. We believe in a new approach of working, with values and in a positive environment - We are a team of entrepreneurs who work hard every day to make Doctolib possible. We have built a philosophy of action based on humility and passion. Want to transform healthcare with us? Check out our open jobs today!

Clarify health’s integrated analytics platform cuts through the fog. we enable you to select the best providers, map and predict patient journeys, and understand the use and impact of therapy on patients. distilling fractured health data into trusted insights. leverage our advanced analytics software to confidently improve physician performance, match patients to the right care, and navigate value-based arrangements. identify top physicians and facilities more accurately, deliver a more personalized experience to members, and maximize value-based engagements. access insights to accelerate product launch and growth, demonstrate real-world impact, and enable outcomes-based commercial agreements. with a deep understanding of healthcare and hospital operations, top-quality enterprise software engineering, and successful cultural transformation experience.

Triomics is revolutionizing the process of data management for clinical research by leveraging EHR interoperability and machine learning.