Top Tech Startups in South Carolina, US in 2026

THE PROMISE With ultrasound a doctor can see into the heart of someone in cardiac arrest or into the abdomen of a woman with an ectopic pregnancy, and save their lives. 75 years after its invention, ultrasound remains an indispensable tool for diagnosis and monitoring. THE PROBLEM 60% of the world lacks access to medical imaging because current technologies are unwieldy, expensive, and require extensive training. While doctors carry supercomputers in their pockets, they still rely on the 200-year old stethoscope​ as their primary diagnostic tool. THE SOLUTION Our mission is to democratize healthcare by making medical imaging accessible to everyone around the world. Butterfly Network has raised >$350M to develop and commercialize a handheld, smartphone-connected ultrasound probe powered by AI. We operate at the intersection of medicine, engineering, and machine learning to create breakthrough technology that becomes smarter with each new patient.

Chowbus is a food ordering platform which curates featured dishes from selected ethnic restaurants daily and delivers them fresh and hot to your home or office affordably with the tap of your cell phone. We provide dish-centric mobile ordering experience for consumers to easily explore and order authentic ethnic food and we empower local ethnic restaurants with the technology, tools, and marketing to grow their business.

T-Rex has been recognized as a “fastest growing company” on the Inc. 5000 list. We’re blazing new paths in federal government IT modernization and transformation with our deep technical expertise in Systems Integration and Development, Cloud Adoption and Infrastructure Optimization, Cybersecurity, Data Engineering and Analytics, and Mission Critical Services.

At 4Catalyzer we strive to transform 21st century medicine by solving today’s most challenging problems – across life science research tools, medical devices and therapeutics. We aspire to create significant societal impact and are motivated by the idea that our products will change the lives of people we love. Fundamentally, we are focused on developing new types of sensors and pairing them with deep learning to get a window into biology and medicine that nobody has ever had before. We have audacious plans – but we have an unbeatable team and a founder that has disrupted biomedical science successfully more than once. If you have experience in image reconstruction, mixed-signal IC design, high-speed electronics, nanophotonics, microfabrication, MEMs, biophysics, biochemistry, molecular biology, deep learning, cloud computing, embedded systems, or hold any dual degree with distinction along with computer science please contact us and “put a dent in the universe”.

Founded in 2013, DoorDash is a San Francisco-based technology company passionate about transforming local businesses and dedicated to empowering new ways of working, earning, and living. Today, DoorDash connects customers with their favorite local and national businesses in more than 1,000 cities across the United States and Canada. By building intelligent, last-mile delivery technology for local cities, DoorDash aims to connect people with the things they care about — one dash at a time.

Metabase is bringing data tools with the elegance and simplicity of consumer products to the crufty world of enterprise business intelligence. Our Open Source analytics and business intelligence application let installs in minutes, and can connect to most commonly used databases. It lets anyone in your company quickly ask questions, and create dashboards or nightly emails without knowing SQL. We provide an opinionated open source starting point for how companies should measure, analyze and share their data as well as a suite of tools to deal with the complexity that arises as they grow.

The Inside Sales Solutions approach builds on more than 20 years of experience selling and leading inside teams. We’ve seen what works and what doesn’t – and how each company needs its own formula for successful sales – and we put that expertise to work uncovering new opportunities for high-tech companies large and small. We are a premier inside sales agency with an entrepreneurial focus and a collaborative environment. We have a startup culture and influence global tech leaders - IBM, Oracle, HP, and McAfee to name a few.

Pomelo Care is the national leader in evidence-based healthcare for women and children. We deliver personalized, high-quality clinical interventions from reproductive care and pregnancy, infant care and pediatrics, to hormonal health through perimenopause and menopause, with long-term preventive care and condition management. Our model delivers 24/7 multispecialty care to address the medical, behavioral, and social factors that most significantly impact outcomes for women and children. We partner with payers, employers, and providers to expand access to quality healthcare across the system. To search career opportunities or to learn more, head to pomelocare.com.

Archesys provides a wide range of technical services and has been doing so for over 20 years, making a significant impact in the areas of organization, culture, and technology in both the private and public sectors. From digital modernization to process management, our team is the go-to resource for various government agencies looking to improve or overhaul their operations.

FOSSA provides the technology to help organizations understand what’s in their code and automate license tracking/compliance without slowing development. Replacing manual systems, FOSSA automatically scans code to analyze license data, generates disclosures/attribution and surfaces issues all on a continuous basis. This allows companies to automate compliance in the background, letting developers write software safely, quickly and in real-time without introducing layers of people and process.