Top Tech Startups in New England, United States in 2026

Based on clinical whole genome sequencing (WGS) and using a single patient sample, Variantyx's Genomic Unity® test identifies and reports all major variant types including small sequence changes, structural variants, mitochondrial variants and short tandem repeat expansions. This comprehensive test test eliminates the need for traditional step-wise, reiterative genetic testing.

Automated Tire (ATI) is a trailblazing Series-A startup dedicated to transforming the tire-changing and wheel-balancing industry through innovative robotic technology. Founded by a team of seasoned entrepreneurs with deep expertise in the tire and automotive sectors, ATI is positioned to redefine the future of automotive service. Our Mission: ATI is overhauling the century-old tire-changing process. Frustrated by the inefficiencies and outdated methods prevalent in the industry, our founders set out to create a solution that integrates cutting-edge robotics to streamline tire service. Our goal is to deliver a faster, safer, and more efficient experience for customers, tire shops, and dealerships alike. What Sets Us Apart: Innovative Robotic Technology: Leveraging state-of-the-art robotics, ATI enhances the speed and accuracy of tire-changing and balancing, setting new standards in the industry. Experienced Team: Our team includes top talent from the Boston robotics community, with a proven track record in scaling successful startups and pioneering technological advancements. Strategic Backing: Supported by leading investors from the automotive and tire sectors, ATI is well-positioned for rapid growth and long-term success.

Big Leap is an award-winning Digital Marketing Company founded on trust and focused on relationships. Our motto is, "Earn Trust Every Day" and we do this by doing what we say, checking our ego at the door, inspiring confidence, and investing in relationships. Our team and client satisfaction guide us as we strive to create the best agency to offer digital marketing services and a wonderful place for people to work.

Anuly is an AI-driven payment integrity platform built for the self-funded healthcare ecosystem. Employers, TPAs, brokers, and payer organizations use Anuly to prevent improper payments before dollars move. We intervene earlier in the payment lifecycle—often before a claim is paid and, in many cases, before it is even created—across the health plan, provider, and member.