Top Tech Startups in California, US in 2026

At TalkDoc, we understand that having a mental illness is an extremely isolating experience, where most people don't even believe you suffer from a mental illness, or downplay what that might mean in your life. Patients who suffer from severe mental illness such as psychosis often go untreated until they hit the breaking point because of this. Talkdoc provides mental healthcare to patients on Medicaid, in more than 5 counties in California, through our professional corporation partnership. TalkDoc has established itself by having the best outcomes in the entire country for Medicaid. We see mental health hospital utilization rates of 0.16% per year, as compared to 3%-4% for the general Medicaid population who sees a mental health clinician. We've helped thousands of people live healthier and happier lives. We are moving from a family business to high-growth startup, and we started that three months ago. Our technology mission is to be the safest and most private form of healthcare, that keeps patient data private long-term, while still offering the most advanced technological solutions, such as AI clinical assistants in workflows.

E-Commerce Platforms, Subscription Platforms, Booking Platforms, Membership Platforms, Hubspot & Ontraport Integration, Multivendor Marketplaces, Accounting Integration Xero, Custom Payment Gateways

Farmers Business Network connects farmers and their data through our independent agronomic network. We seek to improve the livelihood of farmers by making their data useful and accessible. Farmers Business Network (FBN) provide farmers with product performance, yield analysis, yield benchmarking and predictive analytics based on real world performance data from thousands of fields. FBN utilizes data science and machine learning to provide members with insights about each of their fields, powered by billions of data points from our network.

Oportun (Formally Progreso Financiero) is a mission-driven, high growth financial services company providing credit-building, affordable loans that help the financially underserved Hispanic community build a better future. What Makes Oportun Unique? Our Platform: We’ve built a technology platform that enables Oportun to quickly assess an applicant’s likelihood to repay a loan, even those who do not have a credit score. Why Join Oportun? At Oportun, we have a great opportunity to expand the access of our product offering to the community we serve by shipping more innovative technology. In addition to your technical prowess, the most important attributes we hire for are accountability + culture fit. We are a tightknit team that loves to ship, have fun and who genuinely care about each other… so if you love to work in a high-performance team, this is the place for you.

Mon Ami a women-founded, mission-driven startup building the next generation of SaaS for senior services to enable the delivery of life-sustaining social services for older adults. We're going after a $100B+ senior services market where the customers are currently not tech-enabled and are wasting 60% of their time on administrative paperwork that can be digitized and automated. Founders have deep expertise in healthcare and aging, and two prior exits with software companies. Venture-backed by Cowboy Ventures, Felicis Ventures, Maverick Ventures, and Freestyle Ventures.

We make the world's networks safer by providing a rich, unique data source for network traffic analysis.

SmithRx is a next-generation pharmacy benefit partner built on a modern technology platform that creates new levels of flexibility, efficiency, and customer satisfaction. It’s a new path forward that aligns incentives and harnesses data analytics to deliver an exceptional pharmacy benefit product. A San Francisco based technology company, SmithRx was founded in 2016 to create a cost-competitive PBM that offers clients a proven pass-through model, a single platform technology, concierge level service, and strong drug cost, rebate, and service level guarantees. The 100% in-house team brings together experience from healthcare companies including Anthem and Safeway Pharmacy along with Silicon Valley technology leaders. Front-line clinicians guide plan execution and member support. Find out more at smithrx.com

Our mission is to make technical advances towards robots and humans working together side by side, with an emphasis on human-centric design. Diligent Robotics is developing a suite of artificial intelligence that enables robots to collaborate with and adapt to humans in everyday environments. Our first product is a hospital service robot that can assist clinical staff with logistical tasks, allowing them to spend more of their time on direct patient care, improving patient satisfaction, quality of service, and safety.

Vannevar Labs builds software for the country's most critical national security problems. We are uniquely qualified to succeed in this $740B market; our founders have 30 years of combined experience across national security, government sales and CIA, In-Q-Tel, DoD/JSOC, Harvard, and Stanford. We're supported by a number of VCs, including Felicis, DFJ Growth, Point72, Costanoa, and General Catalyst, amongst others. We believe our military service members and intelligence officers deserve access to the best technology American innovation can offer, and we are building great products for this mission. If you're someone who wants to work with conscientious people on things that matter, we'd love to hear from you!

Squint is a Silicon Valley based software company backed by Sequoia Capital (investors in Apple, Google, Instagram, and more) and Menlo Ventures (investors in Uber, Siri, and more). Our team has deep expertise in Augmented Reality — over 45 foundational patents and past work featured in Apple Event keynotes. Squint’s mission is to accelerate human potential by bringing digital knowledge into the real world. Our team has developed the only AR product in the world that is truly “open world” — that is: it can be created anywhere, on the spot, and doesn’t require a QR code or a 3D model to detect objects and orient itself precisely.