Top Software Startups in 2027

With traditional production, a TV commercial can cost $2M and take months to make. So small brands go unseen by patients, and big brands rerun the same spot. ohohoh.ai is an NYC-based tech startup and production studio on a mission to change how medicines reach patients. We produce tasteful commercials for pharma brands end to end with AI, in weeks instead of months, ready for CTV, YouTube, and Meta. Our clients range from emerging biotechs to global pharma companies. We bring creative taste, brand and patient storytelling, and AI-native tools we build ourselves. If you want to make real work at the frontier of AI filmmaking, built to reach millions of patients, we’d love to meet you.

Adaptive is the AI bookkeeping platform for construction. We automate bills, receipt capture, budgets, and draws so you can prevent cash leakage, protect margins, and save hours each week. We are trusted by 700+ of the country's best builders.

Kodo is the Customer Delight Platform that helps brands turn customer understanding into lasting loyalty. We connect customer data, research, rewards and engagement so brands can deliver relevant experiences, give people reasons to return and grow the value of every relationship. Our platform brings real-time customer profiles, surveys, offers, loyalty programs, personalized communications and monetization together. Brands can connect the systems they already use and start with the capabilities that matter most to their business. Kodo Studio works alongside their teams to design, launch and improve their customer programs. We are building a platform that makes every customer feel like the only one. Join us to work directly with the founders, shape how we grow and help build the team around you. Learn more at kodo.co.

Towami is building modern commerce infrastructure for independent merchants across the Americas. We eliminate the painful trade-off between monopolistic marketplaces that take a 15–30% cut of every order and website builders that leave merchants stranded without organic traffic. We give merchants the best of both worlds: high-performance, white-label storefronts on their own domains paired with one-click distribution into a network of regional marketplaces and vertical classifieds. Our business model is pure subscription SaaS — zero transaction commissions, zero revenue share. Hard Problems We’re Solving • Extreme Performance as a Core Moat: Page speed directly determines conversion rates, search rankings, and infrastructure margins. We built a compiled, server-rendered multi-tenant architecture engineered to hit 100/100 PageSpeed scores and green Core Web Vitals on every storefront. It delivers instant page loads without script bloat at a fraction of legacy SaaS hosting costs. • Multi-Region Scale on a Single Codebase: We currently operate across 9 live markets in North and Central America (including the US, Mexico, Costa Rica, and Panama). Provisioned automatically via Cloudflare for SaaS, each country has its own localized catalog, language, and currency, while multi-tenant billing and data remain unified. Launching in a new country is a configuration switch, not an engineering rewrite. • Organic-First Network Effects: Merchant catalogs feed our regional marketplace indexes, and marketplace search traffic directs buyers back into merchant stores. This creates a compounding flywheel: as more stores join, organic search reach expands and customer acquisition cost (CAC) decreases for everyone on the platform. We are an engineering-driven team building scalable, high-margin software that gives independent businesses true ownership of their brand, customers, and margins.

Uplane (YC F25) replaces marketing agencies with AI. We generate hundreds of ads with matching landing pages and steer the ad spend across channels like Meta, Google, LinkedIn and others. By connecting to CRM and ERP data, Uplane learns what drives profits and continuously improves campaigns. Companies waste billions on bad ads, mismatched landing pages, and poor budget allocation. Uplane fixes this by replacing a patchwork of agencies, spreadsheets, and siloed tools with one self-improving system. The result: Higher ROAS for enterprises and effortless, expert-level marketing for SMBs.