Top Digital Health Startups in 2026

Sema4 is a next-generation health information company, spun out of the Mount Sinai Health System, that provides advanced genomic testing and merges big data analytics with clinical diagnostics. Our team creates practical tools that help patients, clinicians, and researchers better diagnose, treat, and prevent disease. We are striving to construct a more comprehensive picture of health by integrating three key elements: a wealth of clinical experience that informs the answers that patients and providers are seeking, the world-class academic research that illuminates new directions, and the pioneering information science that puts all the pieces together.

We are the developer of PrecisePK, a Bayesian dose-optimizing software. It combines the latest pharmaceutical research with machine learning methods such as Bayesian optimization to individualize and precisely compute the drug dosages given to patients.

Charlie Health has set out on a mission to reimagine how high acuity care is delivered to teens and young adults—particularly those in rural populations. We’re building the world’s first infinitely scalable, virtual-first mental health practice. Our initial offering is a virtual intensive outpatient program (vIOP), which connects like-minded virtual groups with therapists that specialize in their specific mental health needs.

Tidepool is a 501(c)(3) nonprofit organization with the mission of making diabetes data more accessible, actionable, and meaningful by liberating data from diabetes devices, supporting researchers, and providing great, free software to the entire diabetes community, including people living with diabetes and their healthcare providers. Tidepool Loop is a project to build and support an FDA-regulated version of Loop, to be available in the iOS App Store, intended to work with commercially available insulin pumps and CGMs.

Clinia enables organizations to leverage first-party health and demographic data to deliver ultra-personalized health navigation, connecting patients into trusted pathways within the health ecosystems of care providers, health systems, insurers, employers, and other health tech startups.

About 1to1help Our mission: Enabling positive changes in people’s lives 1to1help is India’s leading Employee Assistance Programme provider, providing emotional health care to millions of employees and their dependents in India. Our goal is to ensure that the members we care for, are not only able to cope with stress, sadness, anger and anxiety but are primed to improve their sense of purpose, their satisfaction with life and overall happiness We are a 20-year-old company that have been online from the get-go and have a proprietary case management system that supports all our operations. We cover 2.7M employees (not including dependants), work with 800 organisations and have completed close to 1 million counselling interventions to date. We have also addressed over 8500+ suicide risk cases during this time.

At Blooming Health, our mission is to power healthy aging-in-place for all. Our next generation engagement platform seamlessly connects older adults and caregivers with service providers in the $575B aging-in-place market. We are empowering older adults to live in their community independently and help aging-in-place service providers to serve more older adults. We are a fast-growing company looking for a mission-driven team players to drive our upcoming growth plans in multiple states across the US.

Eli is a women's health company on a mission to improve lifelong health through continuous hormone monitoring. Hormones impact physical and mental health every day and at every stage of life. Eli offers real-time insights from hormones in saliva that can be tracked continuously over time, unlike traditional testing methods or send-out tests that only provide a single snapshot. With just three simple steps, Eli's at-home technology provides women with personalized hormone profiles to make informed decisions about their health. Eli is filling a data gap to transform how women manage their hormonal health in key areas like menopause, fertility, contraception, and endocrine conditions. Eli has raised a total of $9 million so women can have the information they need to optimize their overall health from puberty to beyond menopause.

At Fitnescity, we make health and wellness testing accessible and convenient. Fitnescity partners with local clinics and labs nationwide to offer consumer-facing tests, along with personal data analytics. We're growing fast as we're building the largest platform of wellness tests. Join us!

At Mira, we innovate and commercialize mobile health diagnostic platforms, through key biometric data tracking, and clinically relevant results analyzing and delivering, for the connection and accuracy of doctors' diagnostic decisions.