Top Tech Startups in California, US in 2027

We've never measured our bodies more precisely. And we've never done less with it. Most health data lives in silos. Your watch doesn't talk to your labs; your labs don't talk to your kitchen. No single app sees the whole picture, so no app can tell you what to actually do. Malkolm is a chief of staff for your body. He connects your whole health picture (wearables, sleep, workouts, meals, and even your lab reports) and turns it into something none of your apps do: clear, personal guidance on what to do today. He learns your baselines, remembers your history, and coaches you through the small daily decisions (when to push, when to recover, what to eat next) that compound into who you become. Your whole health. One clear move. Invite-only, opening soon. Join the waitlist at malkolm.health. Malkolm is a product of Define, Inc.

The global economy doesn’t move people, goods, nor services without the 100M fleet vehicles on the road. At the center of every fleet, is the fleet manager. They’re responsible for evaluating data and making decisions on purchasing, maintaining, training, reporting, and upselling. Yet a majority of these managers still rely on Outlook and Excel to get their job done. Colin, Drake, and Jamie are the co-founders of Proaction, a growing B2B SaaS startup with one mission: make fleet management simple. We leverage AI to rapidly deploy software that fits our fleet managers’ day-day like a glove.

CommodityAI builds software and AI agents for physical commodity trading—the industry that moves the world's energy, metals, and agricultural products. Behind every trade and shipment, teams coordinate contracts, documents, logistics, and payments across emails, spreadsheets, and existing systems. We turn that scattered information into reliable workflows, helping commercial, logistics, and finance teams keep records in sync, handle routine work, and focus on exceptions that need their judgment. Our agents work with real operational data and tools to support execution across the trade lifecycle. The engineering challenge is making them useful and dependable: connecting complex systems, handling messy inputs, evaluating behavior, and knowing when to bring a person into the loop. We are a Y Combinator W24 company based in San Francisco. We recently raised our Series A and are growing our engineering team. Engineers work closely with the founders and customers, own meaningful parts of the product from idea through production, and see their work used in real operations. We're building a team that values ownership, practical technical judgment, and clear communication. If you enjoy turning ambiguous problems into software people rely on, we'd like to meet you.

Governments and industry leaders are racing to prepare for the quantum future, but assessing the progress towards utility-scale quantum computation remains a challenge. To help decision-makers navigate this rapidly evolving field, Apollo provides rigorous, independent evaluations of quantum computing technologies. Our expertise in algorithms, compilation, error correction, and resource estimation enables us to deliver clear, unbiased assessments that support informed strategic planning.

Archy’s modern software helps dental practices work smarter by reducing everyday friction and equipping teams with AI-powered tools so providers can focus on delivering great care while we handle the complexity of running the practice.

SkyAccess is a US-based private jet marketplace for empty leg flights: private jets repositioning without passengers, which usually sell 25 to 75% below a comparable full charter. SkyAccess is the world's largest empty leg marketplace by listing volume, with 5,000+ live empty leg flights from 900+ FAA Part 135 (and international equivalent) certified charter operators across North America, Latin America, Europe, the Caribbean and beyond. Travelers search and book empty leg flights directly on SkyAccess, with no membership required. Prices are for the whole aircraft, and taxes and fees are shown at checkout. Popular routes connect New York, Miami, Los Angeles, Dallas, Scottsdale and Las Vegas, plus international flights to Mexico, the Bahamas, Canada and Europe, with new empty legs added throughout the day.