Top B2B Startups in 2026

Hesperos, Inc. is a leader in efforts to characterize an individual's biology with Human-on-a-Chip microfluidic systems. Founders Michael L. Shuler and James J. Hickman have been at the forefront of every major scientific discovery in this realm, from individual organ-on-a-chip constructs to fully functional, interconnected multi-organ systems. With a mission to revolutionize toxicology testing as well as efficacy evaluation for drug discovery, the company has created pumpless platforms with serum-free cellular mediums that allow multi-organ system communication and integrated computational PKPD modeling of live physiological responses utilizing functional readouts from neurons, cardiac, muscle, barrier tissues and neuromuscular junctions as well as responses from liver, pancreas and barrier tissues.

The agency search is broken. Directories give you lists. RFPs take weeks. Proposals are impossible to compare. Matchii fixes the process. Describe your project, choose your budget, and we match you with a verified agency that fits, based on skills, availability, and track record. One match. No shortlists. No back-and-forth. Credits go directly to your agency. Milestones release on your sign-off. Everything is tracked in one place. Brief. Match. Deliver.

Reflex is an open-source, full-stack Python framework that allows you to quickly design and deploy web projects.

BURNOUT Venture Syndicate deploys AI-augmented strike teams to help companies solve their hardest problems faster. We bring together independent operators, builders, researchers, strategists, creatives, and unconventional problem-solvers who use modern tools to expand what small teams can do. We are not building another agency, staffing firm, or automation shop. We are building a new model for work: high-agency people, organized around real missions, using AI to amplify human talent rather than replace it.

Bizee provides business formation and compliance services for new and existing companies. The platform supports LLC, S Corporation, C Corporation, and nonprofit formation, along with DBA filings and name searches. Services include registered agent, EIN/Tax ID acquisition, operating agreements, and organizational documents. Ongoing filings cover annual reports, amendments, foreign qualification, certificates of good standing, and dissolution. Bizee also offers business license research, trademark applications, and virtual address solutions. Tools include online dashboards, document storage, and compliance reminders. Educational resources outline entity types, taxes, and state requirements.