Top Tech Startups in Spain in 2027

TP53 is a bootstrapped Italian software house building AI products for healthcare professionals. Cibus is the AI CRM for nutritionists and dietitians. Writing a meal plan used to take hours: gram by gram, food by food, balancing every macro by hand. Cibus writes the plan in minutes, following the nutritionist's own method, with the numbers already balanced. It also handles patients, appointments, documents and invoicing in one place. Scriva is an AI clinical scribe: it listens to the visit and writes the clinical notes, so doctors and therapists can focus on the patient instead of the keyboard. We're growing across Italy and now expanding into Spain. Small team, high pace, no investors telling us what to do: we build what our customers actually need.

Axo Longevity is building Europe’s first high-performance longevity platform: deep blood panels (100+ biomarkers, 2x per year), elite athlete benchmarking, and an AI health copilot, all wrapped in a beautiful, consumer-grade product. We target high performers: athletes, founders, operators, and longevity-focus humans. With a €499/year membership that gives them pro-level data, dashboards, and personalized guidance built GDPR-first and ready to scale across Europe. On the clinical side, we have the guidance of a top level sports Dr. Niko Mihic(Real Madrid FC medical advisor) and Andy Walshe, phd (ex Redbull high performance), plus a growing waitlist of performance-driven members, beta users and creator partners.

The AI-powered pre-construction software helping estimators win more bids and win more business. Automatically detect, measure, compare and label project spaces and features on architectural plans and drawings in seconds, not hours.

Hi! We are ElevenYellow We're a dynamic, creative software lab driven by a passionate team of entrepreneurial innovators. We don't just build software: we push the limits of what's possible, crafting game-changing projects that leave a lasting impact. Our culture is built on flexibility, collaboration, and an insatiable curiosity, giving us the freedom to explore, create, experiment and disrupt in exciting new ways. With over a decade of transforming bold ideas into groundbreaking reality, we're nowhere near done. Honestly, it’s pretty hard to sum up what we do - and we mean that in the best way possible. We’re the kind of company where, when your friends and family ask what you do for work, you’ll probably just shrug and say, “It’s complicated.” And we wouldn’t have it any other way.

Angels.Space is building the first adult creator platform where every model is AI-generated. No real creators. No management teams. Every photo, every video, every personality is produced by AI. We are replacing the creator economy model with one that keeps 100% of revenue, scales without human creators, and improves automatically as AI advances. Pre-launch. Founding team. Moving fast.