Top Drug Development Startups in 2027

BetterUP is the first mobile platform that provides evidence-based personalized coaching to boost your confidence and performance at work. We like to think of it as “executive coaching for everyone.” The app provides 1-on-1 coaching and bite-sized learning to build personal and professional skills like managing stress, increasing concentration, engaging with peers, and honing your competitive advantage. As Millennials increasingly enter the workplace, the demand for coaching will continue to grow. They are the most stressed generation and are not receiving the support they want. Over 75% of Millennials wish their manager was more of a coach. They are seeking coaching that's proven, affordable, and optimized for their busy, on-the-go lifestyle. We teamed up with behavioral scientists, psychologists, health experts, Navy SEALs, Olympic medalists, and executives to pioneer a new breed of business coaching, one rooted in evidence-based science that is highly accessible.

OUR STORY For decades, patients and caregivers have experienced firsthand that only a select few ALS patients have access to the best clinics, testing and treatment options. We were told not to waste our time trying to understand our particular version of ALS but instead accept a care system and generic therapies that did nothing to change the outcome of the disease. Like cancer before, a better way is now possible for all ALS patients. Thanks to advances in science, technology and computational analytics we are beginning to be able to identify and treat each patient’s unique disease. Synapticure was built by leading patient and caregiver advocates alongside leading ALS clinicians, biotech executives and telemedicine executives to bring the ALS care and treatment experience into the 21st century.

3Brain's high resolution biosensor allows to perform non-invasive and long-term studies on brain cells to improve predictions of compounds and to find new treatments for brain disorders.

Our physics-based computational platform integrates differentiated solutions for predictive modeling, data analytics, and collaboration to enable rapid exploration of chemical space. The Schrödinger platform is deployed by industry leaders worldwide for drug discovery, as well as for materials science in fields as diverse as aerospace, energy, semiconductors, oil and gas, automotive, and electronics displays. The platform also powers our own drug discovery efforts, from target identification to hit discovery to lead optimization. It also drives our research collaborations to develop novel medicines for critical public health needs. With more than 150 Ph.D. scientists on our team, we invest heavily in R&D. We’ve published over 400 peer-reviewed papers that demonstrate the strength of our physics-based approaches, and we’re continually pushing the limits of computer modeling.

Olema is a preclinical biotechnology company developing new drugs for the treatment and prevention of estrogen receptor (ER) positive breast cancer. The company focuses on the discovery, development, and commercialization of targeted therapies for women's cancers. It leverages the knowledge of the molecular action of the ER to design compounds that are superior to both the current drugs and those in development. Olema leverages their deep understanding of endocrine-driven cancers, nuclear receptors, and mechanisms of acquired resistance with the goal of transforming the standard of care for pre- and post-menopausal women living with cancer by developing more convenient and effective therapies.