Top Tech Startups in United States in 2026

BioLM is building the API layer for biological language models - making it easy to program DNA and proteins like software. We provide inference, tokenization, and fine-tuning APIs purpose-built for biological sequences, enabling researchers and developers to generate, analyze, and optimize DNA and amino acid sequences at scale. On top of our APIs, we’re building scientific interfaces that make these models usable in real workflows - from sequence design to iterative experimentation. Our goal is to make modern AI-native biology accessible to anyone building in biotech.

Settle is an AI-native enterprise data migration platform and service. We run migrations end to end at a fixed, scoped price, or license the platform to teams that migrate continuously. The approach: AI proposes every mapping and transform, deterministic engines validate every row — schema, referential integrity, business rules, and live workflow replay in the target's own front end — and humans approve before anything loads. Nothing reaches production on the model's judgment alone. Why it works: about 90% of enterprise data maps cleanly. Migrations fail on the other 10% — the exceptions, edge cases, and one-off rules that live in experts' heads and usually surface only after load. Settle captures those rules up front in discovery, then proves every record against them before cutover, not after. Typical migrations complete in days rather than months, priced roughly half the equivalent consulting-led cost, with no billable-hour meter. We handle ERP, CRM, HRIS, LegalTech and other migrations across 100+ paths, including Salesforce, SAP S/4HANA, NetSuite, Oracle, Microsoft Dynamics 365, and Workday. Every engagement ships with audit-grade deliverables: a migration runbook, mapping spec, and full activity log. Built by the team that ran Fortune 500 migrations by hand at Deloitte.

Lotus is making world-class primary care free for everyone, powered by real doctors and AI. We unify your records, labs, wearables, and insurance data into one secure place to deliver personalized, doctor-reviewed care instantly, in any language. Built with clinicians from Stanford, Harvard, and Johns Hopkins and backed by Kleiner Perkins and leaders from Oura, Microsoft, and other pioneering companies —Lotus is a direct-to-consumer health brand redefining what care means: continuous, proactive, and personal. Lotus: world-class primary care, free — powered by real doctors and AI.

What we are building: Nullgen is a localized data loss prevention (DLP) browser extension and administrative platform. The product operates on a freemium model, with the premium enterprise and education tiers offering centralized management, zero-touch MDM deployments, and tamper-proof policy enforcement. The hard problems we are solving: - Enterprise Shadow AI: Employees constantly leak proprietary company code and sensitive financial data into unvetted public LLMs. We stop this data loss locally before the prompt ever hits the network. - K-12 Academic Integrity: Students easily bypass traditional DNS school filters to use AI for essays and tests. We provide district IT administrators with an impenetrable, device-level roadblock. - Privacy-Preserving Security: Traditional DLP software requires routing traffic through third-party servers. Because our custom ML model runs entirely on the user's local device, zero payload data ever leaves the machine, ensuring total data privacy and massive reductions in cloud compute costs.

Take2's AI Interviewers automate the end-to-end screening process -- evaluating resumes, conducting phone screens, and scheduling 2nd interviews with qualified candidates. Our AI Interviewers help reduce overhead costs while boosting speed-to-hire and preventing mis-hires. We are a team of Stanford GSB alums, backed by SemperVirens & Reach Capital. Our advisory board consists of HR Leaders from Visa, HP, Disney & Google.