Top Life Sciences Startups in 2027

We are working on building software to enable you to use your brain tomorrow the way you use a mouse and keyboard today, and hardware to enable the next generation of computing.

80% of our immune system lives in the gut. And this is established in the first 1,000 days of life. Tiny Health is the first at-home gut health testing company developed for expecting moms and babies 0-3 years of age, which dictates the child's lifelong health and potential risks for eczema, allergies, asthma, autism and other chronic diseases later in life. Processed in a CLIA-certified lab and using proprietary technology, our test provides strain-level precision and a complete list of ALL microbes in your gut and vaginal microbiomes - any bacteria, fungi, parasites, archaea, and viruses. Every report includes a personalized interpretation and is reviewed by a team of microbiologists, immunologists and maternal/pediatric nutritionists. More importantly, Tiny Health provides actionable, evidence-based insights and recommendations based on results, to give each baby the best possible start in life. Tiny is the best and most affordable test for parents to monitor and optimize their baby’s gut health development in those crucial early years. We are backed by the top founders and operators in technology and health from Coinbase, GoogleX, TrendMD, StartX Med, Hinge Health, Calm, Signos, Roblox, Walmart Labs, Dropbox, Recogni, Awesome People Ventures, Wisdom Partners and Parenthood Ventures - as well as The Venture City, Conscience VC, Polymath Capital, Hustle Fund, and OnDeck Runway.

The architectures that power modern AI were designed for language, not for science. They were never built to understand DNA, interpret experiments, or learn the rules that govern living systems. Closing this gap represents one of the defining opportunities of our time. Our team has pioneered advances across frontier AI, including the first models trained with one-million-token context windows, and now scaling toward one billion. We focus on innovations on systems and architecture, because building AI for science demands a fundamentally different foundation. As a first application of this technology engine, we are advancing AI for life, the most complex and consequential domain of all. We are the AI team behind Evo and Evo 2, the generative genomics models used to create real gene-editing tools and the first whole genomes designed entirely by AI. That work demonstrated that AI can create biology, not just analyze it. We are now building multimodal models trained directly on the fabric of biology, enabling faster discovery, deeper understanding, and entirely new capabilities. As we push the frontier of scientific world models, we will build systems hand-in-hand to ensure global biological resilience: rapid detection, rapid response, and rapid countermeasures against emerging threats, both natural and synthetic. Our mission is ambitious: to reimagine what AI can do for science, and to build that future.

We're building Rhizome AI to help life science companies always know what their regulator thinks. We're looking for a talented product engineer to help us refine our platform and expand our capabilities. Revenue is up 3x in the last few months, we’re expanding the team to keep up with demand!

Headquartered in San Francisco, Deffai is an AI-native VC-backed seed-stage startup building an AI platform for simulating FDA regulatory intelligence, built together with former FDA reviewers. We help therapeutics companies and their investors anticipate regulatory outcomes. We are ambitious builders with diverse technical backgrounds building vertical AI solutions in a deeply regulated space. Work closely with former FDA decision-makers to redefine the future of biotech approvals. Backed by top-tier tech investors in the SF Bay Area, with advisors from GitHub, OpenAI, and Mercor. Are you an ambitious builder who wants to do more and push the boundary of what's possible? Join our team! Size of the opportunity: FDA accounts for 20% of the U.S. economy alone. Food, drug, and cosmetics. Beyond the U.S., other countries and regions including Canada, Europe, and Japan all have their own FDA with similar frameworks.

Medtronic provides healthcare technology solutions for complex and challenging conditions. They deliver treatments and therapies for the lungs, brain, dental, diabetes, ENT, heart, gastrointestinal, orthopedic, urinary, and women's health. The company's technologies and therapies treat 70 different medical conditions and include patient monitoring systems, robotic surgery, insulin pumps, cardiac devices, and more. Medtronic delivers innovative technologies that change people's lives through to its extensive knowledge, insatiable curiosity, and desire to assist everyone in need.