Senior Bioinformatics Engineer

We're looking for a Senior Bioinformatics Engineer to join our team and help build robust, scalable infrastructure for processing and analyzing next-generation sequencing (NGS) data. This role bridges bioinformatics expertise with production engineering, focusing on creating reliable, high-performance computational pipelines. The ideal candidate will be a seasoned software engineer who can architect robust, scalable systems while working effectively with computational biologists and scientists. They should have a proven track record of building production-grade distributed systems and be excited about applying this expertise to complex biological data processing challenges.

This role offers the opportunity to:

• Design next-generation bioinformatics processing infrastructure
• Solve complex distributed systems challenges
• Work with cutting-edge sequencing technologies
• Build systems that advance biological research and development

Key Responsibilities:

• Design and implement production-grade bioinformatics pipelines for processing NGS data, ensuring scalability, reproducibility, and reliability
• Architect and maintain cloud-native infrastructure for large-scale genomic data processing and analysis
• Build and optimize containerized bioinformatics workflows using modern orchestration tools
• Implement monitoring, alerting, and observability solutions for bioinformatics pipelines
• Develop and maintain CI/CD pipelines for bioinformatics tools and workflows
• Collaborate with scientists, bioinformaticians, and software engineers to translate research methods into production-ready solutions
• Lead technical discussions and architectural decisions for bioinformatics infrastructure
• Establish best practices for version control, testing, and deployment of bioinformatics code and pipelines

What You’ll Bring to the Team:

• Minimum 5 years of experience in software engineering with a Master’s; or equivalent experience.
• Advanced programming skills, with experience in one or more languages such as Python, Rust, or C#.
• Proficient in Linux scripting; demonstrated ability to develop readable, well-documented, and unit-tested code.
• Knowledge of CI/CD tools and practices, including Git, Docker, Kubernetes, and a build management tool such as Jenkins.
• Strong experience with cloud environments and services (AWS S3, EC2, IAM, SNS, SQS) as well familiarity with infrastructure as code languages such as terraform or cloudformation.
• Excellent written and verbal communication skills, with a proven ability to present complex information to both scientific and business stakeholders.
• Demonstrated independence, strategic thinking, and problem-solving abilities in a data-driven environment.

Preferred Qualifications:

• MS/PhD in Bioinformatics, Computational Biology, or related field

• Experience with:

  • Building production bioinformatics systems in a regulated environment
  • Kubernetes for orchestrating containerized workflows and Event-driven architectures and streaming systems
  • Message queuing systems (Kafka, RabbitMQ)
  • Data warehousing solutions (Snowflake, BigQuery)
  • Infrastructure monitoring and observability tools

• Contributions to open-source bioinformatics tools or pipelines

• Background in molecular biology or genomics

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.San Francisco Bay Area Pay Range$140,000—$178,000 USD