Retro careers

We identify aging mechanisms for which interventions have shown robust proofs of concept in mammals and have a feasible path to translation to humans. To start with, we are focused on cellular reprogramming, plasma-inspired therapeutics, and autophagy. Our programs are diversified across mechanism and development stage. We have a molecule in our autophagy program that will enter the clinic in the next year. In our plasma program, we’re characterizing and optimizing plasma interventions in both preclinical and clinical settings, with the first development candidate expected in two years. Our cellular reprogramming effort is closest to fundamental research and farthest upstream in the mechanisms of aging. We will work towards a clinical proof-of-concept over the next four years. To support these three programs, we are investing heavily in single-cell multi-omics, machine-learning-based computational biology, and lab automation.