LOCUS BIOSCIENCES careers

Locus Biosciences is a clinical-stage biotechnology company developing CRISPR-enhanced precision antibacterial products (crPhage™) to address critical unmet medical needs in bacterial infections and microbiome indications in oncology, immunology and neurology therapeutic areas. The Locus platform combines CRISPR-Cas3, which permanently degrades target DNA within a bacterial cell, with bacterial viruses called bacteriophages to specifically kill target pathogens while leaving non-target bacteria (i.e., the rest of the patient’s microbiome) unharmed. Locus completed its first human clinical trial in early 2021, with a crPhage product targeting Escherichia coli bacteria in the urinary tract. Locus also recently announced strategic collaborations with Johnson & Johnson, BARDA, and CARB-X to develop crPhage products targeting respiratory infections, E. coli urinary tract infections, and Klebsiella pneumoniae infections, respectively.