Construction Project Manager

Construction Project Manager

Location: Philadelphia, PA

Company: Orchestra Life Sciences | Full-Time | On-Site

Reports to: Vice President of Construction

About Orchestra Life Sciences

Orchestra Life Sciences is a portfolio-based biopharmaceutical and medical innovation company advancing transformative therapies for patients with high unmet medical needs, including rare diseases and pediatric cancer. Our teams work across disciplines to translate breakthrough science into real-world impact.

Position Summary

The Construction Project Manager is responsible for the full lifecycle delivery of complex construction projects with a focus on life sciences, pharmaceutical, and tenant improvement work. This role requires a seasoned professional capable of managing multiple concurrent projects, leading cross-functional project teams, and serving as the primary client relationship owner from pre-construction through closeout. The Sr. PM operates with a high degree of autonomy and is expected to set the standard for project execution within the organization.

Key Responsibilities

Project Delivery

• Lead all phases of project execution including pre-construction, procurement, construction, and

closeout

• Develop and maintain project schedules using Oracle Primavera and MS Project; identify and

mitigate schedule risks proactively

• Manage project budgets, cost reporting, and CAPEX forecasting with accuracy and consistency

• Oversee subcontractor procurement, scope development, contract administration, and performance

management

• Coordinate with design teams, structural engineers, specialty consultants, and regulatory bodies

including local authorities having jurisdiction (AHJ)

• Manage submittal and RFI processes through Project Management Software; ensure timely

responses and documentation

• Lead OAC meetings, prepare meeting minutes, and maintain clear project communication across all

stakeholders

Life Sciences / Tenant Improvement Specific

• Manage projects within occupied or regulated environments, including GMP, BSL, and cleanroom-

adjacent facilities

• Coordinate tenant improvement work within core and shell constraints, including landlord/tenant

interface management

• Understand and manage requirements related to fire suppression, detection, HVAC, hazardous

materials, and specialty systems common to life sciences facilities

• Support commissioning and validation activities as required by client programs

Team & Client Leadership

• Serve as primary point of contact for owner/client throughout project duration

• Mentor and develop junior project managers and project engineers

• Collaborate with company ownership and internal leadership on pursuit strategy, staffing, and

project reporting

• Identify and escalate project risks, contract issues, and client concerns in a timely and professional

manner

Contract & Risk Management

• Administer prime contracts and subcontracts; manage change order processes with discipline

• Understand and apply insurance program requirements including builders risk, OCIP/CCIP, and

subcontractor default insurance (SDI)

• Ensure project compliance with contract documents, safety requirements, and applicable codes

Qualifications

Required

• Bachelor's degree in Construction Management, Engineering, Architecture, or related field

• 10+ years of construction project management experience, with a minimum of 5 years on life

sciences, pharmaceutical, or technically complex TI projects

• Demonstrated experience managing projects from $10M to $100M+

• Proficiency in Oracle Primavera (P6 or Cloud), MS Project, Procore, and Bluebeam

• Strong understanding of construction contracts (AIA, ConsensusDocs), subcontract administration,

and change management

• Experience coordinating with regulatory bodies and navigating permitting processes

Preferred

• PMP, CCM, or LEED certification

• Experience with GMP, BSL-2/BSL-3, or cleanroom construction environments

• Experience with owner-controlled or contractor-controlled insurance programs (OCIP/CCIP)

Key Competencies

• Exceptional organizational and time management skills with ability to manage multiple projects

simultaneously

• Strong written and verbal communication; comfortable presenting to ownership, clients, and

executive stakeholders

• High attention to detail with a bias toward proactive problem solving

• Collaborative team leader who holds themselves and others accountable

• Operates with integrity and professionalism in all client and subcontractor relationships

Why Join Orchestra Life Sciences

• Opportunity to contribute to innovative therapies with meaningful patient impact
• Collaborative, mission-driven culture across multiple innovation hubs
• Competitive compensation and comprehensive benefits
• Professional growth and leadership development opportunities