The Enhanced Games
Member, Scientific and Ethical Advisory Commission
Alexander Bisignano
Seasoned engineer and technical founder with over a decade of experience building scalable, secure, and highly specialized software platforms in digital health.
Seasoned engineer and technical founder with over a decade of experience building scalable, secure, and highly specialized software platforms in digital health.
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Experience
BillionToOne
VP of Business Development
BillionToOne is the second largest prenatal testing laboratory with its proprietary Quantitative Counting Template (QCT) technology powering category defining cell-free DNA... more tests. I was responsible for all Business Development efforts at BillionToOne, including large commercial partnerships, strategic accounts and large health systems. I developed business development strategy, inclusive of selling strategies and implementation of business development sales systems.
Phosphorus
Co-Founder & Chief Technology Officer, Chief Executive Officer
Phosphorus Genomics built medical genetic tests to help diagnose and prevent adult-onset genetic diseases utilizing next generation sequencing (NGS) technology.
- Raised... more >$25M of financing from institutional and individual investors.
- Built organization from 0 - 80+, navigating through the COVID-19 pandemic.
- Directed engineering and product development teams for a clinical-grade genomics platform.
- Architected web applications including a laboratory information management system (LIMS) and analytics tool utilizing Ruby on Rails, PostgreSQL, Python and Javascript.
- Oversaw the development of bioinformatics pipelines and NGS technologies.
- Scaled technical team and implemented DevOps/HIPAA-compliant infrastructure.
- Achieved 50-state regulatory certification (CLIA) and launched 6 panel-based NGS genomic tests.
- Led business through an acquisition by Kindbody in 2022.
- Raised... more >$25M of financing from institutional and individual investors.
- Built organization from 0 - 80+, navigating through the COVID-19 pandemic.
- Directed engineering and product development teams for a clinical-grade genomics platform.
- Architected web applications including a laboratory information management system (LIMS) and analytics tool utilizing Ruby on Rails, PostgreSQL, Python and Javascript.
- Oversaw the development of bioinformatics pipelines and NGS technologies.
- Scaled technical team and implemented DevOps/HIPAA-compliant infrastructure.
- Achieved 50-state regulatory certification (CLIA) and launched 6 panel-based NGS genomic tests.
- Led business through an acquisition by Kindbody in 2022.
Exit
Recombine
Founder, CEO
Co-founded Recombine, a clinical genetic testing company. Recombine developed the most comprehensive pre-conception genetic test and built a network of IVF Clinics and Ob/Gyn... more offices who utilized test to help prevent severe genetic illness in children. Recombine was sold to CooperSurgical in May of 2016 for $85M.
Founder
Employee
Projects
Software for managing clinical Next Generation Sequencing.
Our software helps hospital pathology and other commercial laboratories to easily deploy state-of-the-art next generation sequencing tests.
Education
About
Achievements
I’m a seasoned engineering leader and technical founder with over a decade of experience building scalable, secure, and highly specialized software platforms in genomics and digital health. With deep expertise in full-stack development, cloud infrastructure, and product architecture, I’ve designed and deployed mission-critical web applications—from LIMS and clinical analytics tools to high-throughput genomics data pipelines—in some of the most regulated environments in healthcare.
I specialize in building from the ground up: I co-founded and led two genetic testing startups (Recombine and Phosphorus), where I architected modern web applications using Ruby, Python, PostgreSQL, and JavaScript, scaling systems to handle millions of data points with HIPAA/CLIA compliance. I’ve led DevOps initiatives on AWS and Heroku, containerized workflows with Docker, and managed teams that bridged engineering, bioinformatics, and product.
My engineering approach combines scientific rigor with pragmatic software design—whether it’s speeding up genomic data turnaround through optimized data pipelines, or building front-end tools that empower team members with real-time insights.
Languages/Frameworks: Ruby, Python, JavaScript, Rails, React, Django, HTML/CSS
DevOps/Infrastructure: AWS, Heroku, Docker
Concepts: Web architecture, data visualization, HIPAA compliance, CLIA workflows, genomics pipelines, startup scaling
Now, I’m excited to continue solving high-impact technical problems—especially at the intersection of healthcare, life sciences, and product-led software engineering.
Describe the most impressive thing you've done.
Skills
Locations